Gestational trophoblastic disease (GTD) is a spectrum of cellular proliferations arising from trophoblast. Their invasive and metastatic potential sometimes requires chemotherapy and/or surgery. Current management is generally associated with favourable prognosis. Therefore, treatments must be chosen according to the desire for further childbearing of each patient. The European Organisation for...

The role of surgery in GTD has been outlined and explained in detail. The importance of accurate diagnosis, clinical assessment, patient resuscitation and support, individualization of management and patient selection has been stressed. The prognosis for patients with GTD is now a successful outcome in 70-100% of cases, depending on the risk factors present. Cerebral lesions still present a poo...

UNLABELLED A Genomic Target Database (GTD) has been developed having putative genomic drug targets for human bacterial pathogens. The selected pathogens are either drug resistant or vaccines are yet to be developed against them. The drug targets have been identified using subtractive genomics approaches and these are subsequently classified into Drug targets in pathogen specific unique metaboli...

We have investigated and applied a hybrid method for the electromagnetic scattering and radiation problem in the mid to high frequency range. The method is based on Geometrical Theory of Diffraction (GTD) and standard Galerkin Boundary Element Method (BEM, also called MM) such that BEM is used on details that are small compared to the wavelength, and the GTD-approximation is used on details whi...

With every nontrivial connected algebraic group G we associate a positive integer gtd(G) called the generic transitivity degree of G and equal to the maximal n such that there is a nontrivial action of G on an irreducible algebraic variety X for which the diagonal action of G on Xn admits an open orbit. We show that gtd(G) 6 2 (respectively, gtd(G) = 1) for all solvable (respectively, nilpotent...

We have investigated two kinds of hybrid methods for the electromagnetic scattering problem in the mid-frequency range. These are, a current-based approximation to the Magnetic Field Integral Equation called Physical Optics (PO) and the ray-based method Geometrical Theory of Diiraction (GTD), both combined with the Method of Moments (MM) such that MM is used on details that are small compared t...

BACKGROUND The aim of this study was to evaluate telomerase activity in tissue from cases of gestational trophoblastic disease (GTD) and in placental tissue from early and late human pregnancies. METHODS We used a telomeric repeat amplification protocol assay to measure telomerase activity in 132 tissue samples from normal early pregnancies, spontaneous abortions, normal late pregnancies, cas...

Choriocarcinoma is a curable malignancy that occurred approximately 50% after term pregnancies, and prognosis in this form of gestational trophoblastic Disease (GTD) is Poor. The earliest onset choriocarcinoma after term pregnancy in one study was reported 3 weeks after delivery, but in current study, choriocarcinoma was diagnosed 2 weeks after delivery. 28 years-old women gravidity 2, parity 2...

Several authors reported lower frequencies of protein sequence convergence between more distantly related evolutionary lineages and attributed this trend to epistasis, which renders the acceptable amino acids at a site more different and convergence less likely in more divergent lineages. A recent primate study, however, suggested that this trend is at least partially and potentially entirely a...