Kaur, Baljeet S., Rodica Ouatu-Lascar, M. Bishr Omary, and George Triadafilopoulos. Bile salts induce or blunt cell proliferation in Barrett’s esophagus in an aciddependent fashion. Am J Physiol Gastrointest Liver Physiol 278: G1000–G1009, 2000.— Barrett’s esophagus (BE) results from acid and bile reflux and predisposes to cancer. We investigated the effect of bile salts, with or without acid, ...

Banks, William A., Cecilia M. Clever, and Catherine L. Farrell. Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice. Am J Physiol Endocrinol Metab 278: E1158–E1165, 2000.— Impaired blood-brain barrier transport of leptin into the arcuate nucleus has been suggested to underlie obesity in humans and outbred aging mice. Here, we used a brain pe...

Gillingham, Melanie B., Elizabeth M. Dahly, Hannah V. Carey, Melanee D. Clark, Karen R.. Kritsch, and Denise M. Ney. Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats. Am J Physiol Gastrointest Liver Physiol 278: G700–G709, 2000.— Patients with severe short-bowel syndrome (SBS) often require long-term total parenteral nutrition (TPN) to maintain the...

HINDRIK MULDER,1,2 SAMUEL GEBRE-MEDHIN,3,4 CHRISTER BETSHOLTZ,4 FRANK SUNDLER,2 AND BO AHRÉN5 1Section for Molecular Signaling, Department of Cell and Molecular Biology, Lund University, SE-221 00 Lund; 2Section for Neuroendocrine Cell Biology, Department of Physiological Sciences, Lund University, SE-221 85 Lund; 3Section for Molecular and Cellular Physiology, Department of Physiological Scien...

Peripheral arterial disease (intermittent claudication) is typically age-dependent and is not uncommon after the age of about 65 years. Exercise training in peripheral arterial disease leads to an increased walking distance and reduced pain, and likely also a slowed progression of the disease process itself. For optimal effect, the exercise should be carried out as walk training, preferably int...

Kreisman, Stuart H., Anthony Manzon, Sharon J. Nessim, José A. Morais, Réjeanne Gougeon, Simon J. Fisher, Mladen Vranic, and Errol B. Marliss. Glucoregulatory responses to intense exercise performed in the postprandial state. Am J Physiol Endocrinol Metab 278: E786–E793, 2000.—A sevento eightfold increment in hepatic glucose production (endogenous Ra) occurs in postabsorptive (PA) intense exerc...

RHONDA C. VANN,1 HANH V. NGUYEN,1 PETER J. REEDS,1 DOUGLAS G. BURRIN,1 MARTA L. FIOROTTO,1 NORMAN C. STEELE,2 DANIEL R. DEAVER,3 AND TERESA A. DAVIS1 1United States Department of Agriculture/Agricultural Research Service Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030; 2United States Department of Agriculture/Agricultural Research...

Forhead, A. J., J. Li, J. C. Saunders, M. J. Dauncey, R. S. Gilmour, and A. L. Fowden. Control of ovine hepatic growth hormone receptor and insulin-like growth factor I by thyroid hormones in utero. Am J Physiol Endocrinol Metab 278: E1166–E1174, 2000.—By use of RNase protection assays, hepatic growth hormone receptor (GHR) and insulinlike growth factor I (IGF-I) mRNA abundances were measured i...

Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic goblet cells is unknown. To address this issue,we havegenerated composite tamoxifen-inducible intestine-specific genetic mouse...

Evans, Jodi F., James K. Yeh, and John F. Aloia. Osteoblast-like cells of the hypophysectomized rat: a model of aberrant osteoblast development. Am J Physiol Endocrinol Metab 278: E832–E838, 2000.—In a previous work, we demonstrated that the osteoprogenitors derived from the marrow stroma of the hypophysectomized (HX) rat demonstrate enhanced proliferative and differentiation capacities when pl...