Tricyclic ring systems, possessing the dibenzo structure joined to the central seven membered heterocyclic ring with a basic side chain, have been a rich source of biologically active molecular entities and frequently show effects on the central nervous system [10]. The precise mechanism of action of these compounds is not known [2]. Therefore to further elucidate the mechanism of action and to...

A rapid and sensitive silver ion high-performance liquid chromatographic (Ag[I]-HPLC) method is developed for the simultaneous determination of the biologically active diterpenoids andrographolide, 14-deoxy-11,12-didehydroandrographolide, 14-deoxyandrographolide, and neoandrographolide in Andrographis paniculata Nees. HPLC is carried out for determining andrographolide and its derivatives with ...