UNLABELLED Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent of disease. Here we evaluated preclinically 4 novel (99m)Tc-labeled small-molecule inhibitors of PSMA with the potential for clinical translation for molecular imaging of prostate cancer in humans. METHODS Fo...

Arthrobacter agilis strain L77, is a plant growth promoting and cold active hydrolytic enzymes producing psychrotrophic bacterium, isolated from Pangong Lake, a subglacial lake in north western Himalayas, India. Genome analysis revealed metabolic versatility with genes involved in metabolism and cold shock adaptation, utilization and biosynthesis of diverse structural and storage polysaccharide...

Four centuries before modern statistical linguistics was born, Leon Battista Alberti (1404–1472) compared the frequency of vowels in Latin poems and orations, making the first quantified observation of a stylistic difference ever. Using a corpus of 20 Latin texts (over 5 million letters), Alberti’s observations are statistically assessed. Letter counts prove that poets used significantly more a...

IMPLICATIONS FOR THERMAL AND CHEMICAL EVOLUTION OF THE EARLY SOLAR SYSTEM. C. D. Williams, R. A. Mendybaev, T. Ushikubo, E. S. Bullock, P. E. Janney, N. T. Kita, F. M. Richter, G. J. MacPherson, and M. Wadhwa, School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287-1404, USA, [email protected], Department of Geophysical Sciences, The University of Chicago, Chicago...

We present the first results of a search for the presence of rapid optical variability in a sample of five Narrow-Line Seyfert 1 galaxies. We find clear evidence of rapid variability for IRAS 13224-3809 with variations occurring on time scales of an hour. However, the results are less conclusive for the other four sources in our sample, Markarian 766, PG 1244+026, PG 1404+226 and Arakelian 564....

*Address correspondence to: Luo Lu, Department of Medicine, David Geffen School of Medicine at UCLA, 1124 W. Carson St., H-H Bldg., Torrance, CA 90502; Tel. (310) 781-1404; Fax. (310) 781-9065; E-mail: [email protected] Capsule Background: CTCF plays important roles in the epigenetic control of cell fate. Results: Hypoxic stress suppressed a higher MW form of CTCF by de-SUMOylation associated with...