Conjugated linoleic acid (CLA) is found in small quantities in dairy and beef products. Obtaining optimum dietary CLA levels from these sources requires an increased intake of saturated fat. A 20% CLA soy oil was produced by UV photoisomerization of soy oil linoleic acid (LA), which is naturally low in saturated fat, but no other high-LA vegetable oils have been studied for their potential as C...

The effects of conjugated linoleic acid (CLA), gamma-linolenic acid (GLA), linoleic acid (LA), and their combinations, on skin composition in mice were investigated. Mice (8 weeks old) were orally administered with either LA, GLA, CLA, LA + GLA, LA + CLA, or CLA + GLA for 4 weeks. Then, the skin was analysed for triacylglycerol content, fatty acid composition and collagen content. Additionally,...

The antioxidative effect of conjugated linoleic acid (CLA) was examined by determining lipid peroxidation and antioxidative enzyme activities. Male Sprague-Dawley rats were fed one of the experimental diets-normal diet, vitamin E-deficient control diet, 0.5% CLA vitamin E-deficient diet, or 1.5% CLA vitamin E-deficient diet for 5 wk. Hepatic thiobarbituric acid reactive substances (TBARS) were ...

compounds with conjugated double bonds in the intermolecule of linoleic acid. CLA was discovered by Kepler et al. in 1966. It has been described as an anticarcinogenic agent in grilled ground beef. Recently, CLA has gained explosive popularity with athletes and body builders in the U.S.A. based on reports of body fat reduction and lean body mass enhancement attributed to it. CLA exerts diverse ...

Conjugated linoleic acid (CLA) induces insulin resistance preceded by rapid depletion of the adipokines leptin and adiponectin, increased inflammation, and hepatic steatosis in mice. To determine the role of leptin in CLA-mediated insulin resistance and hepatic steatosis, recombinant leptin was coadministered with dietary CLA in ob/ob mice to control leptin levels and to, in effect, negate the ...

Studies using dietary supplementation of eicosapentaenoic and docosahexaenoic fatty acids (FA) in horses report inconsistent anti-inflammatory results but consistently report an increase in plasma arachidonic acid (C20:4), the major substrate of cyclooxygenase (COX) II inflammatory pathway. Conjugated linoleic acid has shown anti-inflammatory effects in laboratory and food animal species, but e...

Mice raised on a coconut oil (CO)-containing diet for 6 wk prior to the addition of conjugated linoleic acid (CLA) are more sensitive to CLAinduced body fat loss than mice raised on a soy oil (SO)-containing diet. Coconut oil is deficient in essential fatty acids. However the addition of linoleic acid to a CO-containing diet did not alter the enhanced sensitivity to CLA. The objective of this s...

BACKGROUND Psoriasis is an immune-mediated disease typically associated with cutaneous neutrophilic infiltration and Munro microabscesses. Interleukin (IL)-8 is one of the main neutrophil-attracting chemokines. Although keratinocytes have traditionally been considered to be the principal source of IL-8 in psoriasis, we present data that suggest that cutaneous lymphocyte associated antigen (CLA)...

The definition of trans-fatty acids (TFA) was established by the Codex Alimentarius to guide nutritional and legislative regulations to reduce TFA consumption. Currently, conjugated linoleic acid (CLA) is excluded from the TFA definition based on evidence (primarily preclinical studies) implying health benefits on weight management and cancer prevention. While the efficacy of CLA supplements re...

The main objective of this study was to demonstrate the proof-of-principle for the hypothesis that conjugated linoleic acid-paclitaxel conjugate (CLA-PTX), a novel fatty acid modified anti-cancer drug conjugate, could self-assemble forming nanoparticles. The results indicated that a novel self-assembling nanomedicine, CLA-PTX@PEG NPs (about 105 nm), with Cremophor EL (CrEL)-free and organic sol...