The plasma transglutaminase, factor XIIIa (FXIIIa), circulates as a zymogen containing two proteins, A and B, arranged in a noncovalent tetrameric complex, A2B2. Biosynthesis of plasma FXIII has not previously been demonstrated. In the present study, direct evidence has been obtained that two human hepatoma cell lines, Hep G2 and PLC/PRF/5, synthesize and secrete FXIII B protein. Secretion of t...

If the low energy cross section for He + p → He + e + νe, the ‘hep’ reaction, is ∼ > 20 times larger than the best (but uncertain) theoretical estimates, then this reaction could significantly influence the electron energy spectrum produced by solar neutrino interactions and measured in the SuperKamiokande, SNO, and ICARUS experiments. We compare predicted energy spectra for different assumed h...

Following the program, proposed in hep-th/0310113, of systematizing known properties of matrix model partition functions (defined as solutions to the Virasoro-like sets of linear differential equations), we proceed to consideration of non-Gaussian phases of the Hermitean one-matrix model. A unified approach is proposed for description of “connected correlators” in the form of the phaseindepende...

We develop the formalism discussed previously in hep-ph/0601209 and hep-ph/0605246 to construct a kinetic theory that provides insight into the earliest “Glasma” stage of a high energy heavy ion collision. Particles produced from the decay of classical fields in the Glasma obey a Boltzmann equation whose novel features include an inhomogeneous source term and new contributions to the collision ...

Farnesoid X receptor (FXR) belongs to the nuclear receptor superfamily with its endogenous ligands bile acids. Mice with whole body FXR deficiency develop liver tumors spontaneously, but the underlying mechanism is unclear. Moreover, it is unknown whether FXR deficiency in liver alone serves as a tumor initiator or promoter during liver carcinogenesis. This study aims to evaluate the effects of...

Hypoxia promotes the radioresistance of laryngeal carcinomas and CD133 is one of the markers expressed by tumor-initiating, human laryngeal carcinoma cells. In order to investigate whether CD133-positive Hep-2 cells exhibit a radioresistant phenotype and to determine whether hypoxia promotes this phenotype, we performed a series of experiments. Hep-2 cells, and Hep-2 cells stably expressing hyp...

The aim of our work was to compare cytotoxic and membrane-damaging effects of O. majorana L. essential oil and linalool on Hep G2 and to investigate their possible protective (antioxidant) effects against H2O2 induced membrane damage. The oils were investigated by GC and GC-MS and antioxidant activity was evaluated by DPPH and -carotene–linoleic acid assays. Assessment of cell viability was ma...

In this talk we describe the application of the AdS/CFT correspondence for a confining background to the study of high energy scattering amplitudes in gauge theory. We relate the energy behaviour of scattering amplitudes to properties of minimal surfaces of the helicoidal type. We describe the results of hep-th/0003059 and hep-th/0010069 for amplitudes with vacuum quantum number exchange and, v...

If the low energy cross section for He + p → He + e + νe, the ‘hep’ reaction, is ∼ > 20 times larger than the best (but uncertain) theoretical estimates, then this reaction could significantly influence the electron energy spectrum produced by solar neutrino interactions and measured in the SuperKamiokande, SNO, and ICARUS experiments. We compare predicted energy spectra for different assumed h...