We introduce a liability-threshold mixed linear model (LTMLM) association statistic for case-control studies and show that it has a well-controlled false-positive rate and more power than existing mixed-model methods for diseases with low prevalence. Existing mixed-model methods suffer a loss in power under case-control ascertainment, but no solution has been proposed. Here, we solve this probl...

Dear Editor, I read with interest the study done by Chua and colleagues1 on the attitudes of first-year medical students towards older adults and their willingness to consider a career in Geriatric medicine (GRM). It was a survey of a cohort of 250 firstyear medical students prior to any clinical exposure at the National University of Singapore (NUS) and their attitudes were measured on the UCL...

Penelitian ini bertujuan untuk menganalisis karakteristik instrumen tes Higher Order Thinking Skill (HOTS) matematika SMA dengan konteks kehidupan Tanjung Palas. Jenis penelitian merupakan kualitatif pendekatan deskriptif. Subjek adalah peserta didik kelas XII sebanyak 100 orang. Instrumen HOTS yang dikembangkan berupa Two Tier Multiple Choice (TTMC) 7 butir. Data skor diperoleh dianalisis teor...

هدف: پژوهش حاضر با هدف تعیین نقش تعاملی خود­شفقت ­ورزی زوجین در تنظیم شناختی هیجان خود و همسر به روش مدل­سازی وابستگی متقابل عامل-شریک انجام شد. روش: از نوع توصیفی_همبستگی مدل­ یابی معادلات ساختاری بود. جامعه آماری شامل کلیه ساکن شهر تهران سال 1399 بود که بین آن‌ها 167 زوج (334 شرکت ­کننده) نمونه­ گیری دردسترس ­عنوان نمونه انتخاب برای گرداوری داده­ ها پرسشنامه راهبردهای تنظیم­ هیجان_فرم کوتاه گ...

When studying the history and evolution of the GRM, one of its outstanding features has been its continuous energy dedicated to developing machines, systems and, in recent years, software that would better serve composers’ views and intentions. Unique discoveries were made that have become the fundamental concepts of sound manipulation and have influenced researchers and developers in the conce...

A major roadblock towards accurate interpretation of single cell RNA-seq data is large technical noise resulted from small amount of input materials. The existing methods mainly aim to find differentially expressed genes rather than directly de-noise the single cell data. We present here a powerful but simple method to remove technical noise and explicitly compute the true gene expression level...

We present the software design principles, algorithms, and utilities of a general weighted grammar library, the GRM Library, that can be used in a variety of applications in text, speech, and biosequence processing. Several of the algorithms and utilities of this library are described, including in some cases their pseudocodes and pointers to their use in applications. The algorithms and the ut...

This paper describes how the RM-ODP approach for system specification is applied to the description of the IT architectures of a large Swiss bank. The IT organization of UBS AG is defining several architectures based upon a business model which describes the main objectives of the bank considering the IT requirements. The semantics and the components of each architecture are explained using the...

هدف: بر اساس مطالعه، بسیاری از دانشجویان، سال اول دانشگاه را یکی دوره‌های زمانی پراسترس و چالش‌زای زندگی می‌دانند قادر به سازگاری مناسب با آن نیستند. مطالعه حاضر هدف شناسایی تجارب زیسته دانشجویان پایین در خصوص مشکلات چالش‌های انجام شد. روش: روش پژوهش کیفی نوع پدیدارشناسی بود. داده‌ها استفاده مصاحبه نیمه ساختاریافته جمع‌آوری شد رویکرد 7 مرحله‌ای کلایزی مورد تجزیه تحلیل قرار گرفت. جامعه کلیه آزاد...