To date, empirical literature has generally been considered lacking in relation to neuroendocrine carcinomas (NECs), the highly malignant subgroup of neuroendocrine neoplasms. NECs are often found in the lungs or the gastroenteropancreatic (GEP) system and can be of small or large cell type. Concentrating on GEP-NECs, we can conclude that survival times are poor, with a median of only 4-16 mont...

Although recent epidemiological evidence indicates that the prevalence of non-functioning gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) is rising, a significant number of GEP-NETs still present with symptoms related to the secretion of biologically active substances leading to the development of distinct clinical syndromes. In the past, these syndromes were associated with substant...

BACKGROUND Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) express insulin-like growth factor (IGF)-related factors [IGF1, IGF2; insulin receptor (IR)-A, IR-B; IGF-binding protein (IGFBP) 1-3] as well as somatostatin (SSTRs) and dopamine D2 receptors (D2Rs). OBJECTIVES To (1) compare mRNA expression of IGF-related factors in human pancreatic NET (panNET) cell lines with that in human ...

PURPOSE Peptide drugs for antineoplastic therapies usually have low oral bioavailability and short in vivo half-lives, requiring less preferred delivery methods. Lanreotide depot is a sustained-release somatostatin analog (SSA) formulation produced via an innovative peptide self-assembly method. Lanreotide is approved in the USA and Europe to improve progression-free survival (PFS) in patients ...

PURPOSE The role of growth factors in ovarian cancer development and progression is complex and multifactorial. We hypothesized that new growth factors may be identified through the molecular analysis of ovarian tumors as they exist in their native environment. EXPERIMENTAL DESIGN RNA extracted from microdissected serous low malignant potential (LMP) and invasive ovarian tumors was used to co...

Quadratic eigenvalue problems (QEPs) appear in almost all vibration analysis of systems, such as buildings, circuits, acoustic structures, and so on. Conventional numerical method for QEPs is to linearize a QEP as a doublly-sized generalized eigenvalue problem (GEP), then call a backward stable algorithm to solve the GEP, for example, the QZ for dense GEP, and at last recover approximated eigen...

Different techniques are used to model the relationship between temperatures, dew point and relative humidity. Gene expression programming is capable of modelling complex realities with great accuracy, allowing at the same time, the extraction of knowledge from the evolved models compared to other learning algorithms. We aim to use Gene Expression Programming for modelling of dew point. General...

Correspondence to A.R. Moghassem email: [email protected] ABSTRACT This study compares capabilities of two different modelling methodologies for predicting breaking strength of rotor spun yarns. Forty eight yarn samples were produced considering variations in three drawing frame parameters namely break draft, delivery speed, and distance between back and middle rolls. Several topologies with dif...