BACKGROUND Current guidelines on chronic spontaneous urticaria (CSU) suggest a treatment based on a 3-step approach that aims at total symptom control, starting with H1-antihistamines. However, a significant number of patients present an antihistamine-resistant urticaria that must be treated with an alternative third-line therapy such as omalizumab. METHODS Patients with a history of CSU who ...

OBJECTIVES (1) To explore individual perceptions on experiences of people receiving and/or delivering a shared-care clozapine serviceand (2) to gain an understanding of effectiveness and acceptability of shared-care clozapine. DESIGN Interpretative phenomenological analysis guided the delivery and analysis of a semistructured interview and focus group study designed to explore participant exp...

Abstract Excessive rainfall is difficult to forecast, and there a need for tools aid Weather Prediction Center (WPC) forecasters when generating Rainfall Outlooks (EROs), which are issued the contiguous United States at lead times of 1–3 days. To address this need, probabilistic forecast system excessive rainfall, known as Colorado State University Machine Learning Probabilities (CSU-MLP) syste...

Chronic urticaria (CU) is a skin condition characterized by the presence of intensively pruritic lesions occurring intermittently or continuously for more than 6 weeks. Because the cause(s) of CU are often not known, it is usually referred as chronic spontaneous urticaria (CSU) or chronic idiopathic urticaria (CIU). It affects 0.1%–0.3% of children. Moreover, solar urticaria (SU) is a rare chro...

Isoleucine, leucine and valine are synthesized via a common pathway in which the first reaction is catalysed by AHAS (acetohydroxyacid synthase; EC 2.2.1.6). This heterotetrameric enzyme is composed of a larger subunit that contains the catalytic machinery and a smaller subunit that plays a regulatory role. The RSU (regulatory subunit) enhances the activity of the CSU (catalytic subunit) and me...

EcoCAR 2 is the premiere North American collegiate automotive competition that challenges 15 North American universities to redesign a 2013 Chevrolet Malibu to decrease the environmental impact of the Malibu while maintaining its performance, safety, and consumer appeal. The EcoCAR 2 project is a three year competition headline sponsored by General Motors and U.S. Department of Energy. In Year ...

AIM To contribute to the understanding of the pathogenesis of chronic spontaneous urticaria (CSU) by identifying its relationship with autoimmunity and cytokines using the autologous serum skin test (ASST) and peripheral blood mononuclear cell culture (PBMC) method. MATERIAL AND METHODS Interleukins (IL)-4, IL-10, transforming growth factor (TGF-β1), interferon (IFN)-γ, IL-17A, and IL-23 leve...

Previous studies indicate that 25-45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU) and ...

BACKGROUND Chronic spontaneous urticaria (CSU) poses problems with respect to high prevalence, reduced quality of life, lack of long term efficacy, and expense of current treatments for severe intractable symptoms. There have been many reports suggesting 'stress' factors may be implicated, but there are no studies that explore the efficacy of treatments including a psychological perspective. A ...