Polyelectrolyte multilayer (PEM) films, established using the layer-by-layer (LbL) technique, are attractive for controlled drug delivery in order to improve tissue regeneration. For instance, the LbL-deposition provides the possibility to incorporate biomolecules via electrostatic interactions for drug delivery, which might be moreover combined with a stable biofunctionalization via covalent b...

Correlation analysis of mid-arm circumference (MAC), weight-for-age and weight-for-height obtained from 807 Malay preschool children aged 12-71 months show that MAC had a relatively low correlation with weight-for-age (r = 0.59, P < 0.001) and weight-for-height (r = 0.63, P< 0.001). MAC percentiles and sensitioity-specificity analysis indicate that when weight-for-age and weight-for-height were...

Ascidian embryogenesis is regarded as a typical ‘mosaic’ type. Recent studies have provided convincing evidence that components of the posterior-vegetal cytoplasm of fertilized eggs are responsible for establishment of the anteroposterior axis of the embryo. We report here isolation and characterization of a novel maternal gene, posterior end mark (pem). After fertilization, the pem transcript ...

Replication of time series in microarray experiments is costly. To analyze time series data with no replicate, many model-specific approaches have been proposed. However, they fail to identify the genes whose expression patterns do not fit the pre-defined models. Besides, modeling the temporal expression patterns is difficult when the dynamics of gene expression in the experiment is poorly unde...

BACKGROUND Protein-energy malnutrition (PEM) is a common condition among patients admitted to hospitals, and it is associated with a worse prognosis and increased mortality. Although several screening systems have been developed, PEM is still poorly recognized, and there is no consensus on which test is more reliable and feasible in clinical practice. Prealbumin (PAB) is a potential useful PEM ...

Suppression of zygotic transcription in early embryonic germline cells is tightly linked to their separation from the somatic lineage. Many invertebrate embryos utilize localized maternal factors that are successively inherited by the germline cells for silencing the germline. Germline quiescence has also been associated with the underphosphorylation of Ser2 of the C-terminal domain (CTD-Ser2) ...

Resolving distinct biochemical interaction states when analyzing the trajectories of diffusing proteins in live cells on an individual basis remains challenging because of the limited statistics provided by the relatively short trajectories available experimentally. Here, we introduce a novel, machine-learning based classification methodology, which we call perturbation expectation-maximization...

OBJECTIVE To describe the patient population, diagnoses, and disposition of children and adolescents referred by Pediatric Emergency Medicine (PEM) physicians to a Pediatric Psychiatric Crisis Clinic (PCC) for urgent consultation; to describe the percent agreement between PEM physician discharge diagnosis and subsequent child psychiatrist diagnoses. METHOD Data were obtained prospectively ove...

The rate of generation of reactive oxygen species (ROS) within the polymer electrolyte membrane (PEM) of an operating proton exchange member fuel cell (PEMFC) was monitored using in situ fluorescence spectroscopy. A modified barrier layer was introduced between the PEM and the electrocatalyst layer to eliminate metal-dye interactions and fluorescence resonance energy transfer (FRET) effects dur...