نتایج جستجو برای: روش ضریب داده پرت محلی lof
تعداد نتایج: 466811 فیلتر نتایج به سال:
تشخیص دادههای نویز(پرت یا غیرعادی) از دادههای جریان در شبکه‌های توزیع آب در مرحله آماده‌سازی و پیش‌پردازش داده‌ها برای دستیابی به دادههای تاریخی قابل اعتماد انجام می‌گیرد؛ که در بهبود روش‌های ارزیابی و مدیریت نشت و بهره‌برداری مؤثر از شبکه، مهم و ضروری است. هدف از ارائه این مقاله توسعه یک متدولوژی جدید بر مبنای روش‌های یادگیری بدون نظارت، جهت شناسایی دادههای پرت یا غیرعادی در یک مجموعه دا...
BACKGROUND High platelet reactivity (HPR) after clopidogrel treatment is linked to an increased risk of periprocedural myocardial infarction (PMI). The occurrence of PMI that could be associated with CYP2C19 genotype status was our hypothesis. METHODS AND RESULTS A total of 233 patients with non-ST elevation acute coronary syndromes (NSTACS) undergoing uneventful elective percutaneous coronar...
Pleuropulmonary blastoma (PPB) is the most frequent pediatric lung tumor and often the first indication of a pleiotropic cancer predisposition, DICER1 syndrome, comprising a range of other individually rare, benign and malignant tumors of childhood and early adulthood. The genetics of DICER1-associated tumorigenesis are unusual in that tumors typically bear neomorphic missense mutations at on...
The body and fins of the zebrafish grow rapidly as juveniles and slower as they reach maturation. Throughout their lives, the fins grow isometrically with respect to the body. Growth of individual fin rays is achieved by the distal addition of bony segments. We have investigated the genetic control of mechanisms that initiate new segments or control size of newly initiated segments. We find tha...
در این مقاله پس از تشریح روش پرت دلایل عدم کارایی این روش بیان می گردد. آن گاه استفاده از تابع توزیع احتمال با رویکردهای مختلف آن به عنوان یک روش جدید معرفی می شود . این روش نواقص روش پرت را که ناشی از فرض های ساده کننده و غیر واقعی آن است برطرف می نماید. فرض هایی که باعث می شوند زمان تکمیل پروژه با استفاده از روش پرت کمتر از زمان واقعی آن تخمین زده شود.
This research aimed to analyse the effect of biopesticide and organic liquid fertilizer on weight and quality of apple. The study was carried out in Bumiaji, Batu, East Java (805'S, 11280'E, 1400 m in altitude) on July December 2013. The liquid organic fertilizer (LOF) was produced from water mixed with nitrogen source such as manure, urin, legume leaves, phosphoric powder and an energy sourc...
CYP2C19 loss-of-function (LOF) alleles adversely affect clinical outcome of clopidogrel therapy. Recent introduction of a newer-generation drug-eluting stent (DES) has significantly reduced the occurrence of stent thrombosis.The aim of this study was to evaluate the impact of CYP2C19 LOF alleles on clinical outcome in patients treated with the newer-generation DES.The effects of CYP2C19 genotyp...
Identification of protective loss-of-function (LoF) mutations holds great promise for devising novel therapeutic interventions, although it faces challenges due to the scarcity of protective LoF alleles in the human genome. Exploiting the detailed mechanistic characterization of animal models of validated disease mutations offers an alternative. Here, we provide insights into protective-variant...
Cardiac contraction and relaxation are regulated by conformational transitions of protein complexes that are responsible for calcium trafficking through cell membranes. Central to the muscle relaxation phase is a dynamic membrane protein complex formed by Ca2+-ATPase (SERCA) and phospholamban (PLN), which in humans is responsible for approximately 70% of the calcium re-uptake in the sarcoplasmi...
The metabolome is a collection of small molecules resulting from multiple cellular and biological processes that can act as biomarkers of disease, and African-Americans exhibit high levels of genetic diversity. Exome sequencing of a sample of deeply phenotyped African-Americans allowed us to analyze the effects of annotated loss-of-function (LoF) mutations on 308 serum metabolites measured by u...
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