In this work, a series of arylpiperazine derivatives were synthesized and screened by in vivo pharmacological trials. Among the tested compounds, 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-1-phenylethanone (18) and 2-(4-(2,3-dimethylphenyl)piperazin-1-yl)-1-phenylethanone (19) exhibited potent analgesic activities in both the mice writhing and mice hot plate tests. They showed more than 70...

Results: On the hot plate model ED50 value was per body weight 0.34 (0.18 0.63) mg/kg of the pyrodazol /i.g, 1.00 (0.59 1.70) mg/kg/of the ketorolac/ i. g. in 90 minutes post administration. On the hot plate model in 0.3 1.3 mg/kg/doses i.m the pirodazol is similar to morphine hydrochloride in dose 2.5 mg/kg i.m. On the tail-flick model ED50 values of the pyrodazol and ketorolac are 1.9 (1.12 3...

This technical note describes a detailed study on wax printing, a simple and inexpensive method for fabricating microfluidic devices in paper using a commercially available printer and hot plate. The printer prints patterns of solid wax on the surface of the paper, and the hot plate melts the wax so that it penetrates the full thickness of the paper. This process creates complete hydrophobic ba...

Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Pl...

Kim, M.H., Kim, S.M., Kim, C.S., Park, S.J., Lee, C.H. and Rhee, J.Y. 2002. Quality of Korean ginseng dried by a prototype continuous flow dryer using far infrared radiation and hot air. Canadian Biosystems Engineering/Le génie des biosystèmes au Canada 44: 3.473.54. This study was performed to examine the effects of infrared (IR)/hot-air combination drying on some quality attributes of Korean ...

This paper presents an integrated high temperature ultrasonic transducer (HTUT) on a sensor insert and its application for real-time diagnostics of the conventional hot embossing process to fabricate V-cut patterns. The sensor was directly deposited onto the sensor insert of the hot embossing mold by using a sol-gel spray technique. It could operate at temperatures higher than 400 °C and uses a...