C holesterol homeostasis is a tightly regulated process. Previous work has been dominated by sterol-response element—related mechanisms, but the influence of micro-RNAs (miRs) is increasingly recognized, with miR-223 becoming a recent member of this group. Several micro-RNAs (miRNAs or miR-) have been reported to be involved in cholesterol homeostasis. 1–4 In a recent study, Vickers et al 5 pre...

science&justice Volume 42 No.4 (2002) 223 – 224 Page 223 *Corresponding author © The Forensic Science Society 2002

Epigenetic modifications regulate developmental genes involved in stem cell identity and lineage choice. NFI-A is a posttranscriptional microRNA-223 (miR-223) target directing human hematopoietic progenitor lineage decision: NFI-A induction or silencing boosts erythropoiesis or granulopoiesis, respectively. Here we show that NFI-A promoter silencing, which allows granulopoiesis, is guaranteed b...

Mosquitoes are serious biting pests and obligate vectors of many vertebrate pathogens. Their immature larval and pupal life stages are a common feature in most tropical and many temperate water bodies and often form a significant proportion of the biomass. Control strategies rely primarily on the use of larvicides and environmental modification to reduce recruitment and adulticides during perio...

(a) P is a nonempty set; (b) ≤ is a partial ordering of P; i.e., ≤ is transitive, reflexive relation in P (and so p ≤ q ∧ q ≤ p ∧ p 6= q is not forbidden); (c) for all p ∈ P, p ≤ 1. (1 need not be the only such maximum element.) We shall often write P for 〈P,≤,1〉. Let P be a poset. If p is an element of P, then an extension of p is a q ∈ P such that q ≤ p. Two elements of P are compatible if th...

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1 Department of Clinical and Toxicological Analysis, University of Alfenas-MG, Av. Gabriel Monteiro da Silva, 714, Alfenas, MG, Brazil, 37130.000 2 Laboratory of Industrial Hygiene and Toxicology, University of Brescia, P.le Spedali Civili, 1, 25100, Brescia, Italy 3 Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Lineu Prestes...

BACKGROUND Macrophage activation plays a crucial role in regulating adipose tissue inflammation and is a major contributor to the pathogenesis of obesity-associated cardiovascular diseases. On various types of stimuli, macrophages respond with either classic (M1) or alternative (M2) activation. M1- and M2-mediated signaling pathways and corresponding cytokine production profiles are not complet...

Atrial fibrillation (AF) is the most common sustained arrhythmia causing high morbidity and mortality. While changing of the cellular calcium homeostasis plays a critical role in AF, the L-type calcium channel α1c protein has suggested as an important regulator of reentrant spiral dynamics and is a major component of AF-related electrical remodeling. Our computational modeling predicted that mi...

On May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium Ra 223 dichloride (Ra-223; Xofigo injection; Bayer HealthCare Pharmaceuticals Inc.) for the treatment of patients with castration-resistant prostate cancer (CRPC), symptomatic bone metastases, and no known visceral metastatic disease. The FDA review was based on clinical trial BC1-06, which randomly allocated patients ...