objective: the use of fetal hemoglobin (hbf) inducer drugs is considered as a novel approach in treatment of β-hemoglobinopathies, especially β- thalassemia and sickle cell disease. hbf inducers including hydroxyurea, histone deacetylase (hdac) inhibitor agents such as sodium butyrate, azacitidine, decitabine and new immunomodulator drugs like pomalidomide, lenalidomide and thalidomide can redu...

conclusions the results of this study reveal that the m. communis extract and methanolic extract of chamomile have a high antibacterial effect on regular and imp-producing p. aeruginosa strains; so, these extracts can be suitable alternatives for less-effective antibiotics, which are commonly used. materials and methods this cross-sectional descriptive study was conducted on burn patients hospi...

conclusions the results suggest that b. coagulans is a good candidate for the fermentative production of phb. background biodegradable polyesters are candidates for the development of environmental friendly plastics. poly-β-hydroxybutyrate (phb) is a type of polyester from the hydroxyalkanoates family, synthesized by bacteria as an intracellular material and accumulated as granules in the cytop...

it is well known that several plant extracts have a lactogenic effect. this response may be inducedthrough the stimulation of prolactin release from lactotrope cells. a partial purification of the activecompound indicated that it is rich in pectin and β-glucan. these materials stimulate secretion of prolactinfrom hypophyseal fragments. in the present study, the effect of β-glucan on the secreti...

conclusions vpa and cbz treatments caused a decrease in β-catenin and vegf levels in sw480 colon cancer cell lines. these results suggest that cbz can be considered a potential antitumor drug with potencies different from vpa. methods in the present experimental study, implemented during 2014 - 2015 in iran, after incubation of cells into 96-well plates with 5,500 cells/well, the tested drugs w...

background:chronic active adrenocorticotropin hormone (acth) immunization of ewes (with a previous history of immunization) resulted in elevated titres of antibody against acth, which induced a reduction in circulating levels of cortisol. objectives:the aim of the present study was to investigate: a) the influence of active immunization against acth on milk production of the ewe as assessed by ...

purpose: to report concomitant angioid streaks and skin lesions in a patient with β thalassemia. patient and findings: a 47-year-old female, a known case of b thalassemia, presented with gradual decrease of vision in her right eye. on indirect ophthalmoscopy of both eyes, angioid streaks were detected. on fluorescencin angiography, hyperfluorescence of streaks without signs of choroidal neovasc...

early and regular blood transfusion therapy in patients with homozygous beta-thalassemia decreases the complications of severe anemia and prolongs survival. in the long term, however, the beneficial effects of transfusions are limited by the organ damage resulting from iron overload. endocrine complications in patients with thalassemia major in developing countries may be frequent due t o subop...