The title compound, C(42)H(72)N(2)O(5), a hindered amine light stabiliser (HALS) with the trade name Tinuvin 144 was prepared from bis-(1,2,2,6,6-penta-methyl-piperidin-4-yl) 2-butyl-malonate and 2,6-di-tert-butyl-4-[(dimethyl-amino)meth-yl]phenol using lithium amide as a catalyst. In the mol-ecule, both piperidine rings adopt chair conformations. In the crystal, inversion dimers linked by pair...

A series of N-aryl heteroarylisopropanolamines in which an indole or a 3-arylpyrrole moiety was linked to an aryl group through an isopropanolamine linker, were designed and synthesized as potential anti-HIV-1-PR agents. Series was tested for their ability in blocking PR activity. As a rule, indole derivatives of class 1 exhibited more potency than pyrrole analogues of class 2 while tert-butyla...

A novel, simple, cheap, and high sensitivity batch chemiluminescent method for the determination of catecholamine drugs, epinephrine (E), dopamine (DA) and methyldopa (MD) at microgram levels in pharmaceutical formulations is described. The method is based on a chemiluminescence (CL) system arising from the reaction of bis(2,4,6-trichlorophenyl) oxalate (TCPO) with H₂O₂ in the presence of a nov...

The accumulation of intracellular organic solutes was examined in six species of the order Thermotogales by nuclear magnetic resonance spectroscopy. The newly discovered compounds di-2-O-beta-mannosyl-di-myo-inositol-1,1'(3,3')-phosphate and di-myo-inositol-1,3'-phosphate were identified in Thermotoga maritima and Thermotoga neapolitana. In the latter species, at the optimum temperature and sal...

A method for the determination of several phthalate esters in water samples using solid-phase extraction coupled to high-performance liquid chromatography was developed. A polytetrafluoroethylene turnings packed column was used as a SPE adsorbent material. The analytes were sorbed on polytetrafluoroethylene turnings, from which they were eluted by a small amount of acetonitrile, followed by a R...

background: phthalates are widely used as plasticizers in polyethylene terephthalate (pet) products. several pharmaceutical products have been stored in pet containers, and due to serious health effects of phthalates, migration levels of them into pharmaceutical products must be determined. in the present study, leaching levels of four common phthalate esters including di-n-butyl phthalate (dbp...