Chalcone derivatives have attracted increasing attention due to their numerous pharmacological activities. Changes in their structures have displayed high degree of diversity that has proven to result in a broad spectrum of biological activities. The present study highlights the synthesis of some halogen substituted chalcones 3(a-i) containing the 5-chlorothiophene moiety, their X-ray crystal s...

The dioxygen we breathe is formed by light-induced oxidation of water in photosystem II. O2 formation takes place at a catalytic manganese cluster within milliseconds after the photosystem II reaction centre is excited by three single-turnover flashes. Here we present combined X-ray emission spectra and diffraction data of 2-flash (2F) and 3-flash (3F) photosystem II samples, and of a transient...

In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds sho...

Auditory function is dependent on the formation of specific innervation patterns between mechanosensory hair cells (HCs) and afferent spiral ganglion neurons (SGNs). In particular, type I SGNs must precisely connect with inner HCs (IHCs) while avoiding connections with nearby outer HCs (OHCs). The factors that mediate these patterning events are largely unknown. Using sparse-labeling and time-l...

4-Substituted-5-iodo-2-benzylthiopyrimidines were prepared efficiently in three steps. 2-Benzylthiopyrimidine on iodination in presence of base gave 5-iodo-2-benzylthiopyrimidine (1), which on chlorination with excess of POCl(3) furnished 4-chloro-5-iodo-2-benzylthiopyrimidine (2). Reaction of 2 with substituted aromatic amines, 2-aminopyridine and hydrazine hydrate yielded 4-amino-5-iodo-2-ben...

Anahtar Kelimeler Kömür atığı, Susuzlandırma, Tikiner, Flokülant, Çöktürme Özet: Bu çalışmada, Dereköy Lavvar Tesisi (Soma, Manisa) tikiner girişinden alınan numune üzerinde anyonik (Akkim Akua 5220, Brentag Brentamer A 2030, Brentag Brentamer A 2530, Bifloc An 254, Minefloc Lot X 4119, 3F Sedifloc 750 AHM), katyonik (Snf 5980 Sl ve 3f Sedifloc 408 C) ve noniyonik (Snf Fa 920) flokülantlar kull...

The common approach to masking Byzantine failures is by replicating the computation and running a Byzantine agreement protocol among all replicas. However, Byzantine agreement incurs high communication overhead and also requires the use of at least 3f + 1 replicas in order to overcome f such failures. However, for many applications, and in particular scientific computation, it is possible to ac...

AIM OF THE STUDY To evaluate the inhibitory effect of 17 new analogues of FPh on the Pgp transport function, by estimation of the rhodamine 123 (Rod-123) accumulation inside cultured lymphocytes. MATERIAL AND METHODS Lymphocyte were cultured in the presence of a lectin (PHA; 2%, v/v), incubated with benzo[α]pyrene (B[α]P; 7.5 µM, 48 h) to induce genotoxic damage and to increase Pgp expression...

Oligodendrocyte precursor cells, which persist in the adult central nervous system, are the main source of central nervous system remyelinating cells. In multiple sclerosis, some demyelinated plaques exhibit an oligodendroglial depopulation, raising the hypothesis of impaired oligodendrocyte precursor cell recruitment. Developmental studies identified semaphorins 3A and 3F as repulsive and attr...

To evaluate the relative importance of local feature and spatial filter models for hyperacuity, vernier thresholds were determined for gratings consisting of a fundamental (Fo) and third harmonic (3F) presented alone, and added together in compound gratings where the relative phase offsets of 3F to Fo was 0, 90, 180 and 270 degrees. Thresholds were determined for a range of spatial frequencies ...