203 words) Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer associated with the Merkel cell polyomavirus (MCV). As MCC cell lines demonstrate oncogene addiction to the MCV T-antigens, pharmacological interference of the large T-antigen (LTA) may represent an effective therapeutic approach for this deadly cancer. In this study, we investigated the effects of interferons (I...

Merkel cell polyomavirus (MCV) is a virus discovered in our laboratory at the University of Pittsburgh that is monoclonally integrated into the genome of approximately 80% of human Merkel cell carcinomas (MCCs). Transcript mapping was performed to show that MCV expresses transcripts in MCCs similar to large T (LT), small T (ST), and 17kT transcripts of SV40. Nine MCC tumor-derived LT genomic se...

Hemoglobin (Hb), mean cell volume (MCV), and erythrocyte protoporphyrin (EP) are commonly used to screen for iron deficiency (ID), but systematic evaluation of the sensitivity and specificity of these tests is limited. The objective of this study is to determine the sensitivity and specificity of Hb, MCV, and EP measurements in screening for ID in preschool children, non-pregnant women 15-49 ye...

M contagiosum virus (MCV) infection occurring in an epidermal cyst (EC) is a very rare condition and only a few cases were reported in children and adults.1-3 However, MCV in multiple small epidermal cysts (ECs) was not previously described. Therefore, this unusual case of molluscum infestation occurring in multiple ECs was presented. A 20-year-old female was evaluated with an asymptomatic, fir...

Adult patients with macrocytosis, defined as a mean corpuscular volume (MCV) greater than 100 femtoliters, were studied to assess the importance of an elevated MCV. After eliminating pregnant and postpartum patients and patients receiving medications known to cause macrocytosis (e.g., phenytoin, zidovudine, and chemotherapeutic agents), 80 patients were identified and studied. Sixty-seven diagn...

BACKGROUND AND AIMS The existence of non-excitable cells in the myocardium leads to the increasing conduction non-uniformity and decreasing myocardial electrical conductivity. Slowed myocardial conduction velocity (MCV) believed to enhance the probability of cardiac arryhthmia and alter the cardiac mechanical pumping efficacy, even in sinus rhythm. Though several studies on the correlation betw...

PURPOSE Erythrocyte mean corpuscular volume (MCV) increase has been described in patients treated with capecitabine. In this study, we sought to evaluate the potential association of the erythrocyte MCV increase with tumor response and survival in patients with metastatic colorectal cancer (mCRC) treated with capecitabine. METHODS A retrospective review of 131 patients with mCRC who were trea...

UNLABELLED Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients in north of Iran. METHODS The serum samples of 150 RA patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commerc...

background: anti-ccp is a test commonly used for the diagnosis of rheumatoid arthritis. the aim of this study was to determine the diagnostic values of accp compared to anti-mcv in rheumatoid arthritis patients in north of iran. methods: the serum samples of 150 ra patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commercially availab...