Ion channel proteins are universal devices for fast communication across biological membranes. The temporal signature of the ionic flux they generate depends on properties intrinsic to each channel protein as well as the mechanism by which it is generated and controlled and represents an important area of current research. Information about the operational dynamics of ion channel proteins can b...

Voltage-sensitive dyes can be used to image cortical network function with millisecond temporal resolution and with a horizontal spatial resolution of approximately 50μm. This imaging technique can be combined with whole-cell patch-clamp CARL C. H. PETERSEN • Laboratory of Sensory Processing, Brain Mind Institute, SV-BMI-LSENS AAB 105, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne,...

The ion channels located on the cell fine structures play an important role in the physiological functions of cell membrane. However, it is impossible to achieve precise positioning on the nanometer scale cellular microstructures by conventional patch-clamp technique, due to the 200 nm resolution limit of optical microscope. To solve this problem, we have established a high-resolution patch-cla...

The recent development of automated patch clamp technology has increased the throughput of electrophysiology but at the expense of visual access to the cells being studied. To improve visualization and the control of cell position, we have developed a simple alternative patch clamp technique based on microfluidic junctions between a main chamber and lateral recording capillaries, all fabricated...

The membrane clamp technique is an important tool to reflect the electrophysiological characteristics of cells by recording ionic currents cellular channels. Embedded systems work in designed for specific user groups and are used implement functions. amplifier built with embedded technology has advantages miniaturization, specialization, low power consumption, high integration, resource utiliza...