BACKGROUND Clinical studies indicate that blood pressure (BP)-lowering effects of radiofrequency (RF) renal denervation (RD) are sustained for up to 2 years, although a recent clinical trial failed to find a major effect compared to sham treatment. In most previous studies, the efficacy of RD has not been assessed. The current study determined whether RD in different regions of the renal artery...

BACKGROUND Although renal denervation (RD) is shown to reduce blood pressure significantly in patients with resistant hypertension, the benefit of RD in prevention of stroke is unknown. We hypothesized that RD can prevent the incidence of stroke and brain injury in hypertensive rats beyond blood pressure lowering. METHODS AND RESULTS High-salt-loaded, stroke-prone, spontaneously hypertensive ...

Numerous studies have shown that packet reordering is common, especially in networks with a high degree of parallelism. Reordering of packets decreases the TCP performance of a network, mainly because it leads to overestimation of the congestion of the network. We consider wired networks with transmission that follows predominantly, but not necessarily exclusively, symmetric routing paths, and ...

A3 Note that each of the sets {1}, {2}, . . . , {n} has the desired property. Moreover, for each set S with integer average m that does not contain m, S ∪ {m} also has average m, while for each set T of more than one element with integer average m that contains m, T \{m} also has average m. Thus the subsets other than {1}, {2}, . . . , {n} can be grouped in pairs, so Tn −n is even. A4 (partly d...

Activity of the CFTR channel is regulated by phosphorylation of its regulatory domain (RD). In a previous study, we developed a bicistronic construct called DeltaR-Split CFTR, which encodes the front and back halves of CFTR as separate polypeptides without the RD. These fragments assemble to form a constitutively active CFTR channel. Coexpression of the third fragment corresponding to the missi...

We study the effects of rounding on moments random variables. Specifically, given a variable X and its rounded counterpart rd(X), we study|E[Xk]-E[rd(X)k]|for non-negative integer k. consider case that function rd: R → F corresponds either to (i) nearest point in some discrete set or (ii) randomly larger smaller this same with probabilities proportional distances these points. In both cases, sh...

OBJECTIVE To investigate the incidence and risk factors for retinal detachment (RD) after cataract surgery or refractive lens exchange (RLE) in patients aged below 61 years. METHODS Retrospective medical chart review of 7,886 patients (13,925 eyes) who underwent cataract surgery or RLE. Patients aged below 61 years were selected. Age, gender, axial length, follow-up times, and the occurrence ...

We investigated the effects of photoreceptor degeneration on the anatomy and physiology of inner retinal neurons in a mouse model of retinitis pigmentosa, the retinal degeneration (rd) mutant mouse. Although there is a general assumption that the inner retinal cells do not suffer from photoreceptor death, we confirmed major changes both accompanying and after this process. Changes include sprou...