Current treatments for patients with Crohn's disease (CD) are based on recent advances in elucidating the pathophysiology of the disease. A satisfactory therapeutic strategy has not been well established. A new sphingosine 1-phosphate (S1P) receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), has been developed for immunomodulation in autoimmune diseases and organ transplantation. W...

Long non-coding RNAs (lncRNAs) have been reported to be of great importance in the formation and progression of a wide range of human carcinomas including prostate cancer (PCa). Among them, PCAT3 and PCAT9 have been identified as two prostate tissue-specific lncRNAs and are up-regulated in PCa. However, their roles in the biological characteristics of PCa have not been fully elucidated. In the ...

Galectin-7, a member of the β-galactoside-binding protein family, is primarily expressed in stratified epithelial cells, including keratinocytes. There is information in the literature suggesting a role for this protein in regulation of keratinocyte survival and growth, but the underlying mechanism remains relatively unknown. Moreover, its expression pattern in the epidermis suggests that it is...

MicroRNAs (miRNAs) are a family of small, non-coding RNAs (17-24 nucleotides), which regulate gene expression either by the degradation of the target mRNAs or inhibiting the translation of genes. Recent studies have indicated that miRNA plays an important role in regulating osteoblast differentiation. In this study, we identified miR-203 and miR-320b as important miRNAs modulating osteoblast di...

tention in a series of 12 patients, according to Sodee, and he discontinued the mercuhydrin injection ( 7 ). McAfee noted that pharmacologists have been unable to block the uptake in the kidneys, despite pre-dosing rats with cold mercurials with doses up to 20 mg of mercury per kilogram, a tremendously toxic dose (8). Although brain scanning with such short-lived isotopes as 99mTcand 197Hg is r...

Pre-eclampsia (PE) is a common but complex condition that can occur in pregnancy. It is estimated to affect 3-8% of pregnancies worldwide. PE development is thought to be multifactorial and to involve the dysregulation of microRNA (miR) expression. However, the precise mechanisms of PE development remain unclear. The present study aimed to illustrate the association between miR‑203 expression a...

Alcoholic liver disease (ALD) is a global liver disease which characterized by liver inflammation, fatty liver, alcoholic hepatitis, or liver cirrhosis. Alcohol abuse is one of the main reasons for liver disease. Alcoholic fatty liver (AFL) disease is the early stage of ALD and associated with the excessive lipids accumulation in hepatocytes as well as oxidative stress. MicroRNA-203 (miR-203) i...

PAGE Part I. Transformation properties of the field equations and conservation laws. . . . . . . . . 203 . Un&ts and notat&on. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 2. The variation principle and the energy-momentum tensor; gauge transformation and current vector. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

23 In many mouse models of skin cancer, only a few tumors typically form even though many cells 24 competent for tumorigenesis receive the same oncogenic stimuli. These observations suggest an 25 active selection process for tumor-initiating cells. Here we use quantitative mRNA-and miR-Seq 26 to determine the impact of Hras G12V on the transcriptome of keratinocytes. We discover that 27 microRN...