BACKGROUND To evaluate the relationship of the intercondylar notch width with unilateral and bilateral ACL injury by using MR images. MATERIAL AND METHODS The intercondylar notch width index was measured on the MR images of 18 patients with a bilateral ACL injury, 38 patients with a unilateral ACL injury and 53 healthy subjects with a normal ACL and the results of all groups were compared wit...

ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA. Our molecular characterizations of the cDNAs and genes coding for the Arabidopsis ACL indicate that the plant enzyme is heteromeric, consisting of two dissimilar subunits. The A subunit is homologous to the N-terminal third of the animal ACL, and the B subunit is homologous ...

For years, bioengineers and orthopaedic surgeons have applied the principles of mechanics to gain valuable information about the complex function of the anterior cruciate ligament (ACL). The results of these investigations have provided scientific data for surgeons to improve methods of ACL reconstruction and postoperative rehabilitation. This review paper will present specific examples of how ...

With the participation of women in athletics growing rapidly over the last two decades, a disturbing gender-specific pre-disposition has emerged regarding anterior cruciate ligament (ACL) injuries of the knee. Female athletes have a two- to eightfold higher incidence of ACL injury than their male counterparts. It is estimated that 38,000 women sustain ACL tears per year. The majority of ACL inj...

Passive collagenous structures such as rabbit medial collateral ligament exhibit fatigue behavior under cyclic loading: the larger the magnitude of repetitive loading, the fewer the number of loading cycles until failure [1]. A knowledge gap exists as to whether the human ACL might also exhibit fatigue behavior under cyclic loading. If so, this would help explain why an ACL rupture can occur du...

The present study compares fibroblasts extracted from intact and ruptured human anterior cruciate ligaments (ACL) for creation of a tissue engineered ACL-construct, made of porcine small intestinal submucosal extracellular matrix (SIS-ECM) seeded with these ACL cells. The comparison is based on histological, immunohistochemical and RT-PCR analyses. Differences were observed between cells in a r...

Anatomic study related to the anterior cruciate ligament (ACL) reconstruction surgery has been developed in accordance with the progress of imaging technology. Advances in imaging techniques, especially the move from two-dimensional (2D) to three-dimensional (3D) image analysis, substantially contribute to anatomic understanding and its application to advanced ACL reconstruction surgery. This p...

Females demonstrated 2-9 times higher ACL injury rate, narrow notch width and higher joint laxity in multi-planar directions [1,2]. One of potential ACL injury mechanisms is ACL impingement against the lateral wall of the femoral intercondylar notch [3], expressed as elongated and deformed ACL geometry [3] and contact area and contact pressure between the ACL and the intercondylar notch [4]. Ho...

Direct anterior cruciate ligament (ACL) repair has been described with different suture techniques after acute ACL injury, but these procedures showed high failure rates. Recent studies, however, led to a better understanding of the biology of primary ACL healing. This article describes a novel technique combining the "healing response technique" with primary anatomic double-bundle ACL reinsert...

Introduction: Until the mechanics of anterior cruciate ligament (ACL) injuries and contributing factors are better elucidated, effective preventive strategies will continue to elude us. Current dogma is that ACL injury results from a single loading cycle, but recent evidence supports tissue fatigue as a possible failure mechanism [1]. In a cadaveric pivot landing model, ACL rupture was found to...