The objective of this study was to compare the blood-brain barrier (BBB) transport and brain distribution of levo (R-CZE) and dextrocetirizine (S-CZE). Methods: Microdialysis probes, calibrated using retrodialysis by drug, were placed into the frontal cortex and right jugular vein of eight guinea pigs. Racemic CZE (2.7 mg/kg) was administered as a 60 min i.v. infusion. Unbound and total concent...

Two coupled channel effects connected with kaon pair production in proton-proton collisions are discussed. (1) Although there is ample evidence that the antikaon is strongly attracted to the recoil protons in pp → Kp {K−p}, residual effects of the KK interaction are seen, including a possible cusp at the KK̄ threshold. This is investigated within a simple K-matrix approach. (2) The production ra...

KP = { z ∈ C | the sequence P ◦k(z) is bounded }. We will write Pc(z) = z2 + c, and Kc, etc., when discussing quadratic polynomials speciˇcally. If P is monic of degree d with KP connected, there is then a unique conformal mapping φP : C − KP → C − $ D which satisˇes φP (P (z)) = (φP (z))d and tangent to the identity at ∞. We call RP (θ) = φ−1 P ({re2π iθ , r > 1}) the external ray of KP at ang...

Let 1 < p ̸= 2 < ∞, ε > 0 and let T : lp(l2) into → Lp[0, 1] be an isomorphism Then there is a subspace Y ⊂ lp(l2), (1 + ε)-isomorphic to lp(l2), such that: T|Y is an (1+ ε)-isomorphism and T (Y ) is Kp-complemented in Lp [0, 1], with Kp depending only on p. Moreover, Kp ≤ (1 + ε)γp if p > 2 and Kp ≤ (1 + ε)γp/(p−1) if 1 < p < 2, where γr is the Lr norm of a standard Gaussian variable.

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and Akt are important regulators of the phosphatidylinositol 3-kinase (PI3K) pathway and thus are important to the regulation of a wide spectrum of tumor-related biological processes. Akt regulates several critical cellular functions, including cell cycle progression; cell migration, invasion, and survival; and angiogenesis. Decre...

Ketoprofen (KP), a nonsteroidal anti-inflammatory drug (NSAID), possesses analgesic, antipyretic and anti-inflammatory properties. Oral KP is widely used in musculoskeletal pain and inflammation in muscles and joints, including arthritis pain, osteoarthritis, stiffness of the joints, soft tissue rheumatism, and sports injuries. In common with all NSAIDs, oral KP has been associated with systemi...

Recently, kisspeptin (KP) and gonadotropin inhibitory hormone (GnIH), two counteracting neuropeptides, have been acknowledged as significant regulators of reproductive function. KP stimulates reproduction while GnIH inhibits it. These two neuropeptides seem to be pivotal for the modulation of reproductive activity in response to internal and external cues. It is well-documented that the current...

UNLABELLED Nosocomial infection caused by extended-spectrum beta-lactamase producing Klebsiella pneumoniae (ESBL-Kp) have been frequently reported worldwide. We have no information on such problems in Bahia, Brazil. OBJECTIVES Evaluate the risk factors for nosocomial infections caused by ESBL-Kp, in a tertiary hospital, in Bahia, Brazil. MATERIAL AND METHODS We evaluated all reported cases ...

Cancer/testis (CT) antigens are considered target molecules for cancer immunotherapy. To identify novel CT antigens, immunoscreening of a testicular cDNA library was performed using serum obtained from a colon cancer patient who was immunized with a new dendritic cell vaccine. We isolated 64 positive cDNA clones comprised of 40 different genes, de...

Toll-like receptors (TLRs) are required for protective host defense against bacterial pathogens. However, the role of TLRs in regulating lung injury during Gram-negative bacterial pneumonia has not been thoroughly investigated. In this study, experiments were performed to evaluate the role of TLR4 in pulmonary responses against Klebsiella pneumoniae (Kp). Compared with wild-type (WT) (Balb/c) m...