Epigallocatechin gallate (EGCG) is the major polyphenol in green tea and the main bioactive compound responsible for the health benefits of tea consumption. The molecule exhibits antimicrobial and anti-inflammatory activities. However, little is known about the molecular mechanisms by which EGCG elicits those activities. In this study, we examined the effects of EGCG on lipopolysaccharide (LPS)...

The major component in green tea polyphenols, epigallocatechin-3-gallate (EGCG), has been demonstrated to prevent carcinogenesis. To improve the effectiveness of EGCG, liposomes were used as a carrier in this study. Reverse-phase evaporation method besides response surface methodology is a simple, rapid, and beneficial approach for liposome preparation and optimization. The optimal preparation ...

The effects of (-)-epigallocatechin gallate (EGCG) on the contraction of floating collagen gel by fibroblasts were investigated. EGCG inhibited collagen gel contraction dose-dependently. On the basis of the fact that platelet-derived growth factor (PDGF) is one of the serum components with stimulatory activity in collagen gel contraction, we examined the possibility that interaction between EGC...

Epigallocatechin-3-gallate (EGCG) is a major constituent of green tea, but its effects on glioma cell growth have not been reported. The aim of this study was to investigate the anticancer effect of EGCG on the growth and invasive ability of glioma cells, as well as the molecular mechanisms responsible for it. Two glioma cell lines were treated with EGCG, and its effect on cell proliferation an...

Inducible nitric oxide synthase (iNOS) is a main enzyme producing nitric oxide during inflammation and thus contributes to the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, has multiple beneficial effects for treating cardiovascular disease, but the effect of EGCG on the e...

background: epigallocatechin gallate (egcg), a major constituent of green tea, has been introduced as a potent free radical scavenger and can effectively reduce free radical-induced lipid peroxidation. since free radical injury plays an important role in neuronal damage in parkinson’s disease (pd), this study examined whether egcg administration would reduce functional asymmetry in an experimen...

BACKGROUND The green tea catechin epigallocatechin gallate (EGCG) was shown to effectively inhibit tumor growth in various types of cancer including biliary tract cancer (BTC). For most BTC patients only palliative therapy is possible, leading to a median survival of about one year. Chemoresistance is a major problem that contributes to the high mortality rates of BTC. The aim of this study was...

BACKGROUND (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant of the green tea polyphenols that exhibit a variety of bioactivities. The objective of this study was to evaluate the anti-fatigue effect of EGCG by forced swimming exercise. MATERIALS AND METHODS The mice were divided into one control group and three EGCG-treated groups. The control group was administered with distilled wa...

Background and Objective: The rate of survival in acute promyelocytic leukemia (APL) can dramatically improve, if the patients receive all-trans-retinoic acid (ATRA) treatment. However, this drugchr('39')s toxicity is a major problem in APL treatment. Previous researches have demonstrated that phyto-polyphenols such as epigallocatechin gallate (EGCG) and kaempferol cause apoptosis in hematopoie...

We previously reported that (-)-epigallocatechin gallate (EGCG) in green tea alters plasma membrane organization and causes internalization of epidermal growth factor receptor (EGFR), resulting in the suppression of colon cancer cell growth. In the present study, we investigated the detailed mechanism underlying EGCG-induced downregulation of EGFR in SW480 colon cancer cells. Prolonged exposure...