objective(s): neuroinflammation in parkinson disease (pd) is associated with glial cells activation and production of different inflammatory cytokines. in this study, we investigated the effect of chronic administration of 8-oh-dpat on 6-ohda-induced catalepsy and levels of inflammatory cytokines in cerebrospinal fluid (csf).   materials and methods: catalepsy was induced by unilateral infusion...

this paper is mainly focusing on the determination of mean molal activity coefficient of hcl in aqueous acidic medium. the present investigations have been carried out to determine the activity coefficients of hydrochloric acid in 2-propanol water mixture solutions under various conditions to study the ion solvent interactions in different temperatures. the standard molar potential em0 of the c...

background & objectives: good fasting practice is not only refraining from foods and drinks in a period of time, but should encompass several important factors including unexcessive eating habit during ifthor. understanding the effect of fasting accompanied by calorie restriction (cr) in oxidative stress indicators, malondialdehyde (mda) and 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxodg), th...

it has been reported that different species of euphorbia (euphorbiaceae) have antitumor activity. some reports also show that these plants have potential cytotoxic effect against different cell lines. in a program to screen the cytotoxicity of iranian native plants, euphorbia macroclada boiss. was collected, identified, and the cytotoxic activity of dichloromethane, ethylacetate, methanol extra...

the uptake and transport of 9-nitrocamptothecin (9-nc), a potent anticancer agent, across caco-2 cell monolayers was studied as a free and plga nanoparticle loaded drug. different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. the transport of nanoparticles across the caco-2 cell monolayer as a func...

the complexation reactions between mg2+, ca2+, sr2+ and ba2+ metal cations with 15-crown-5 (15c5) were studied in acetonitrile (an)-methanol (meoh) binary mixtures at different temperatures using conductometric method. 15c54 forms 1:1 complexes with mg2+, ca2+ and sr2+ cations in solutions. the ma2+ cation forms a 2:1 complex (ratio of lighand to cation) in solutions. a linear relation was obse...

cancer is not just one disease, but a large group of almost one hundred diseases. its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to migrate from the original site and spread to distant sites. if the spread is not controlled, cancer can result in death. there has been continuous progress in the development of therapy for cancer....