RGEs for coefficients of dim-5 operators giving rise to neutrino masses in the seesaw mechanism are written down in the SM, 2HDM and MSSM, and solved numerically. RG evolution of these coefficients modifies tree-level seesaw predictions for neutrino masses and mixing angles in SO(10)-type GUT models as strongly as quark Yukawa coupling evolution. ZU-TH 20/93 DFPD 93/TH/44 ∗ Supported in part by...