We report the case of a 64-year-old male with persistent atrial fibrillation (AF) terminated by ethanol infusion into vein of Marshall as add-on therapy. Three-dimensional automated complex fractionated atrial electrogram (CFAE) during AF revealed clustering of CFAE at perimitral isthmus (PMI) and its unipolar mapping showed rotor-like activation, which was suggested to be critical in the perpe...

Originality, a key aspect of creativity, is difficult to measure. We tested the relationship between originality and similarity in two semantic spaces: latent semantic analysis (LSA) and pointwise mutual information (PMI). Similarity in both spaces was negatively correlated with human judgments of originality of responses on a test of divergent thinking. PMI was correlated more strongly both wi...

The purchasing managers’ index (PMI) is a simple subjective survey about the state of the manufacturing sector of the national economy. It’s an early indicator of the nation’s economic strength with effects extending into federal monetary policy and the financial markets. It is a composite index comprising the weighted average of new orders, production, employment, supplier deliveries, and inve...

We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabeti...

BACKGROUND AND PURPOSE DWI and DTI of the brain have proved to be useful in many neurologic disorders and in traumatic brain injury. This prospective study aimed at the evaluation of the influence of the PMI and the cause of death on the ADC and FA for the application of DWI and DTI in forensic radiology. MATERIALS AND METHODS DWI and DTI of the brain were performed in situ in 20 deceased sub...

The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53, conferring tumor development and survival. Antagonists targeting the p53-binding domains of MDM2 and MDMX kill tumor cells both in vitro and in vivo by reactivating the p53 pathway, promising a class of antitumor agents for cancer therapy. Aided by native chemical ligation and mirr...

This study was designed to examine the relationship between pericardial fluid and plasma CRP levels, and to alterations in other biochemical parameters in patients undergoing Coronary Artery Bypass Grafting (CABG). The study group consisted of 96 Coronary Artery Disease (CAD) patients who were referred to our clinic for a CABG procedure and from whom sufficient amount of pericardial fluid could...

Phosphomannose isomerase (PMI) is an enzyme catalysing the interconversion of mannose 6-phosphate (Man-6-P) and fructose 6-phosphate (Fru-6-P). The reaction catalysed by PMI is the first committed step in the synthesis of mannose-containing sugar chains and provides a link between glucose metabolism and mannosylation. In this study, the pmi1 gene was identified to encode PMI in the human fungal...

The validity of the method in which total body score (TBS) and accumulated degree-days (ADD) are used to estimate the postmortem interval (PMI) is examined. TBS and ADD were recorded for 232 days in northern South Africa, which has temperatures between 17 and 28 °C in summer and 6 and 20 °C in winter. Winter temperatures rarely go below 0°C. Thirty pig carcasses, which weighed between 38 and 91...

A prospective postinfarction follow-up study was used to identify subsets of patients with different survival patterns. Nine hundred forty patients who survived the hospital phase of an acute myocardial infarction were followed for 12-60 months. During the 5-year follow-up, 115 patients died of cardiac causes. Univariate analysis showed that prior myocardial infarction (PMI), left ventricular d...