The miR-58 family comprises 6 microRNAs with largely shared functions, and with an overall high expression, because one of its members, miR-58, is the most abundant microRNA in Caenorhabditis elegans. We recently found that 2 TGF-β signaling pathways, Sma/Mab and Dauer, responsible for body size and dauer formation respectively, among other phenotypes, are downregulated by the miR-58 family. He...

The case, through the experience of a recent college graduate thrusted in the decision-making spotlight, describes the attempt by the largest student travel agency in the world – STA Travel – to evaluate whether and how to establish a presence in Second Life. Second Life was a fast emerging Massive Multiplayer Online Role-Playing Game (MMORPG) that was garnering increasing attention from compan...

The use of ontologies within many information science communities is growing at an ever-increasing rate. This is especially true of higher-level multisource information fusion applications, where there is a genuine need for an improved understanding of the complex relational items (e.g. intentions, capabilities, opportunities and vulnerabilities) typically associated with situation and threat a...

We derive a lower bound for the sta ng levels required to meet a projected load in a retail service facility. We model the queueing system as a Markovian process with nonhomogeneous Poisson arrivals. Motivated by an application from the postal services, we assume that the arrival rate is piecewise constant over the time horizon and retain such transient e ects as build-up in the system. The opt...

The ability to distill specific frequencies from complex spatiotemporal patterns of afferent inputs is a pivotal functional requirement for neurons residing in networks receiving frequency-multiplexed inputs. Although the expression of theta-frequency subthreshold resonance is established in hippocampal pyramidal neurons, it is not known if their spike initiation dynamics manifest spectral sele...

AIM The superficial temporal artery (STA) is the one of the terminal branches of the external carotid artery. Three-dimensional anatomical structure of the STA can be evaluated by using three dimensional volume rendering technique (3D-VRT) from acquired two-dimensional contrast-enhanced computerized tomographic images. MATERIAL AND METHODS The raw data of the Three-dimensional Computerized To...

The purpose of this study was to compare the effects of bicycle seat tube angles (STA) of (72° and 82°) on power production and EMG of the vastus laeralis (VL), vastus medialis (VM), semimembranous (SM), biceps femoris (BF) during a Wingate test (WAT). Twelve experienced cyclists performed a WAT at each STA. Repeated measures ANOVA was used to identify differences in muscular activation by STA....

This paper presents a Computer Aided Testability tool named STA (System Testability Assistant), aiming at proposing a testa-bility strategy for systems as early as possible in the design process. Given a system description, STA rst compiles it in order to create system, boards, and circuits objects, and then proceeds bottom-up, from the circuit to the system, in order to evaluate the actual tes...

A sequence of elements an of R d converges to a limit a if and only if, for each ǫ > 0, the sequence an eventually lies within a ball of radius ǫ centered at a. It’s okay if the first few (or few million) terms lie outside that ball— and the number of terms that do lie outside the ball may depend on how big ǫ is (if ǫ is small enough it typically will take millions of terms before the remaining...

A 62-year-old woman presented with 4 months of neck, shoulder, and hip pain, morning stiffness, and elevated inflammatory markers compatible with polymyalgia rheumatica (PMR). Cervical spine imaging demonstrated ill-defined enhancement in posterior neck soft tissues (figure 1), consistent with interspinous bursitis. She reported right-sided headache. Brain magnetic resonance angiography demonst...