Near the end of 2001 February, the black-hole candidate (BHC) GRS 1758–258 made an abrupt transition from a standard hard (low) state to a soft state. Unlike Cyg X–1 and other BHCs, whose luminosity increases during this transition, GRS 1758–258 was dimmer after the transition. We present observations with the Proportional Counter Array on the Rossi X-ray Timing Explorer and interpret the pheno...

We present revised infrared (2.2μm) astrometry of the field containing the Galactic microquasar GRS 1758−258, using observations at the Keck I 10-m telescope. We find three candidates for the microquasar within a 3σ error circle, but none within 2σ. We show that if the 18.4 day X-ray period of GRS 1758−258 is due to a binary orbit, then only one of the three candidates, an early K-type giant, i...

This paper introduces GRS-based AOP which explains a large subclass of AOP weavers as graph rewrite systems (GRS). The corresponding class of AOP problems has a formal background since it inherits all features of graph rewrite systems such as criteria for termination , connuence, and unique normal forms. In particular, it it shown that diierent kinds of rewrite rules form diierent weaver classe...

Word Grammar (Hudson 1984, 1990), in common with other dependency-based theories of syntax, seeks to express syntactic knowledge in terms of direct relationships between words. Dependency theories have traditionally recognised a large class of primitive grammatical relations (GRs), including Subject, Object and Adjunct, amongst others. In this paper I call into question the status of these GRs,...

OBJECTIVE Resuscitation of critically ill patients requires medical knowledge, clinical skills, and nonmedical skills, or crisis resource management (CRM) skills. There is currently no gold standard for evaluation of CRM performance. The primary objective was to examine the use of high-fidelity simulation as a medium to evaluate CRM performance. Since no gold standard for measuring performance ...

BACKGROUND AND PURPOSE Carotid intima-media thickness (IMT) is a surrogate marker of subclinical atherosclerosis and a strong predictor of stroke and myocardial infarction. The object of this study was to determine the association between carotid IMT and 702 single nucleotide polymorphisms in 145 genes. METHODS B-mode carotid ultrasound was performed among 408 Hispanics from the Northern Manh...

Modulation of n-3 fatty acids on genetic susceptibility to type 2 diabetes (T2D) is still not clear. In a case-control study of 622 Chinese T2D patients and 293 healthy controls, a genetic risk score (GRS) was created based on nine T2D genetic variants. Logistic regression was used to examine the interaction of the GRS with erythrocyte phospholipid n-3 fatty acids for T2D risk. Every 1-unit (co...

BACKGROUND Noninvasive prenatal diagnosis of trisomy 21 (T21) has recently been shown to be achievable by massively parallel sequencing of maternal plasma on a sequencing-by-synthesis platform. The quantification of several other human chromosomes, including chromosomes 18 and 13, has been shown to be less precise, however, with quantitative biases related to the chromosomal GC content. METHO...

OBJECTIVE To test the hypothesis that the statistical effect of obesity-related genetic variants on adulthood adiposity traits depends on birth year. METHODS The study sample included 907 related, non-Hispanic White participants in the Fels Longitudinal Study, born between 1901 and 1986, and aged 25-64.99 years (474 females; 433 males) at the time of measurement. All had both genotype data fr...

BACKGROUND Cumulative genetic profiles can help identify individuals at high-risk for developing RA. We examined the impact of 39 validated genetic risk alleles on the risk of RA phenotypes characterized by serologic and erosive status. METHODS/PRINCIPAL FINDINGS We evaluated single nucleotide polymorphisms at 31 validated RA risk loci and 8 Human Leukocyte Antigen alleles among 542 Caucasian...