The effective use of complex fenestration systems in buildings requires knowledge of their optical spectral and directional properties. While the directional properties are commonly assessed by the measurement of bidirectional transmission or reflection distribution functions, the addition of spectral information would significantly aid in the design and analysis of such systems. This paper des...

BACKGROUND The RAG encoded proteins, RAG-1 and RAG-2 regulate site-specific recombination events in somatic immune B- and T-lymphocytes to generate the acquired immune repertoire. Catalytic activities of the RAG proteins are related to the recombinase functions of a pre-existing mobile DNA element in the DDE recombinase/RNAse H family, sometimes termed the "RAG transposon". METHODOLOGY/PRINCI...

Cre recombinase catalyzes the cleavage and religation of DNA at loxP sites. The enzyme is a homotetramer in its functional state, and the symmetry of the protein complex enforces a pseudo-palindromic symmetry upon the loxP sequence. The Cre-lox system is a powerful tool for many researchers. However, broader application of the system is limited by the fixed sequence preferences of Cre, which ar...

We approximate the double Λ hypernuclei by systems composed by two interacting Λ’s moving in the mean field potential created by the nuclear cores. The Λ-core potentials are adjusted to reproduce the binding energies of the corresponding single Λ hypernuclei [1]. A σ-ω meson exchange potential [2] is used for the Λ-Λ interaction. We apply both the Hartree-Fock (HF) and variational approximation...

BACKGROUND Genetic variation is an essential means of evolution and adaptation in many organisms in response to environmental change. Certain DNA alterations can be carried out by site-specific recombinases (SSRs) that fall into two families: the serine and the tyrosine recombinases. SSRs are seldom found in eukaryotes. A gene homologous to a tyrosine site-specific recombinase has been identifi...

Chromosomally integrated retroviral switch (S) substrates have been developed to reveal switch recombinase-like activities (SRLA) in pre-B and mature B cell lines. Switch substrate retrovectors (SSR) contain a long-terminal repeat-driven neomycin (Neo) gene for proviral chromosomal maintenance (pre- and post-S recombination) and a CMV promoter-driven, chimeric hygromycin-thymidine kinase (Hytk)...