نتایج جستجو برای: γ h2ax

تعداد نتایج: 76297  

2013
Nandan Kumar Mondal Erik Sorensen Nicholas Hiivala Erika Feller Bartley Griffith Zhongjun Jon Wu

OBJECTIVE To study the status of oxidative stress and DNA damage repair in circulating blood leukocytes of heart failure patients supported by continuous flow left ventricular assist devices (LVADs). MATERIALS AND METHODS Ten HF patients implanted with LVAD as bridge to transplant or destination therapy were enrolled in the study and 10 age and sex matched volunteers were recruited as the stu...

Journal: :Human molecular genetics 2013
Lauren A Solomon Bailey A Russell L Ashley Watson Frank Beier Nathalie G Bérubé

ATR-X syndrome is a rare genetic disorder caused by mutations in the ATRX gene. Affected individuals are cognitively impaired and display a variety of developmental abnormalities, including skeletal deformities. To investigate the function of ATRX during skeletal development, we selectively deleted the gene in the developing forelimb mesenchyme of mice. The absence of ATRX in the limb mesenchym...

Journal: :Radiation and environmental biophysics 2014
Helen C Turner P Sharma J R Perrier A Bertucci L Smilenov G Johnson M Taveras D J Brenner G Garty

At the Center for High-Throughput Minimally Invasive Radiation Biodosimetry, we have developed a rapid automated biodosimetry tool (RABiT); this is a completely automated, ultra-high-throughput robotically based biodosimetry workstation designed for use following a large-scale radiological event, to perform radiation biodosimetry measurements based on a fingerstick blood sample. High throughput...

Journal: :Frontiers in Astronomy and Space Sciences 2023

Introduction: Missions beyond low Earth orbit (LEO) will expose astronauts to ionizing radiation (IR) in the form of solar energetic particles (SEP) and galactic cosmic rays (GCR) including high atomic number energy (HZE) nuclei. The gastrointestinal (GI) system is documented be highly radiosensitive with even relatively dose IR exposures capable inducing mucosal lesions disrupting epithelial b...

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