DNA-gold nanoparticle assemblies have shown promise as an alternative technology to DNA microarrays for DNA detection and RNA profiling. Understanding the effect of DNA sequences on the melting temperature of the system is central to developing reliable detection technology. We studied the effects of DNA base-pairing defects, such as mismatches and deletions, on the melting temperature of DNA-n...

Folic acid (FA) was conjugated to superparamagnetic iron oxide nanoparticles to develop a tumor specific contrast agent for magnetic resonance imaging (MRI). In this scheme a bifunctional poly(ethylene glycol) (PEG) linker was utilized to both increase biocompatibility and reduce nanoparticle agglomeration. The uptake of nanoparticle-PEG-FA conjugates by folate-receptor (FR) positive MCF-7 cell...

Chitosan nanoparticle, a biocompatible material, was used as a potential drug delivery system widely. Our current investigation studies were the bioeffects of the chitosan nanoparticle uptake by liver cells. In this experiment, the characterizations of chitosan nanoparticles were measured by transmission electron microscopy and particle size analyzer. The average size of the chitosan nanopartic...

In vivo monitoring of nanoparticle delivery is essential to better understand cellular and molecular interactions of nanoparticles with tissue and to better plan nanoparticle-mediated therapies. We developed a three-dimensional ultrasound and photoacoustic (PA) imaging system and a spectroscopic PA imaging algorithm to identify and quantify the presence of nanoparticles and other tissue constit...

A nanoscale, synthetic perturbation was all that was required to nudge a natural, self–assembly process toward significantly higher order. Nanolithography was used to impose the perturbation which ultimately led to an organized nanoparticle array. Specifically, liquid–phase pulsed laser induced dewetting (PLiD) was used to transform metallic thin film strips into nanoparticle arrays. Initially,...

We investigated the expansion features of femtosecond laser generated tungsten nanoparticle plumes in vacuum. Fast gated images showed distinct two components expansion features, viz., plasma and nanoparticle plumes, separated by time of appearance. The persistence of plasma and nanoparticle plumes are 500 ns and 100 ls, respectively, and propagating with velocities differed by 25 times. The es...

abstract background: radiosensitizer drugs are used to enhance the efficiency of radiotherapy. some nanoparticles can be considered as radiosensitizers, because they enhance cytotoxicity due to oxidative stress and increase free radical yield, especially ros , within cells resulting to cell death. methods: in this study, synergistic effect of tio 2 nanoparticles was evaluated in presence of 60 ...

The field of nanoparticle delivery systems for nutrients and nutraceuticals with poor water solubility has been expanding, almost exponentially, over the last five years, and some of these technologies are now in the process of being incorporated in food products. The market projections for these technologies suggest a multifold increase in their commercial potential over the next five years. T...

Enzymatic ligation of discrete nanoparticle-DNA conjugates creates nanoparticle dimer and trimer structures in which the nanoparticles are linked by single-stranded DNA, rather than by double-stranded DNA as in previous experiments. Ligation was verified by agarose gel and small-angle X-ray scattering. This capability was utilized in two ways: first, to create a new class of multiparticle build...