نتایج جستجو برای: β tubulin gene
تعداد نتایج: 1295916 فیلتر نتایج به سال:
Conjugate of podophyllotoxin with chlorambucil: synthesis, biological testing and molecular modeling
In the present work we have studied a novel conjugate of DNA alkylating agent chlorambucil with podophyllotoxin, ligand colchicine binding site in tubulin. The target compound was obtained by Steglich esterification podophyllotoxin percentage yield 41%. Results biotesting carried out on carcinoma A549 cell line revealed that at concentration 2 μM caused full depolymerization microtubules withou...
این زیر جنس که اغلب از اندام های هوایی غلات در مناطق شمال و شمال غرب و تعدادی هم از سایر بسترها در ایران به دست آمده بودند، مورد مطالعه قرار گرفتند. براساس داده های ریخت شناسی و مولکولی (توالی های مناطق ژنی its rdna و β-tubulin)، تعداد نه گونه aspergillus متعلق به زیرجنس nidulantes شناسایی گردید که در بخش های nidulantes، usti، terrei و flavipedes گروه بندی شدند. آنالیزهای فیلوژنتیکی انجام گرفته...
The hominoid oncogene TBC1D3 enhances epidermal growth factor receptor (EGFR) signaling and induces cell transformation. However, little is known regarding its spatio-temporal regulation and mechanism of tumorigenesis. In the current study, we identified the microtubule subunit β-tubulin as a potential interaction partner for TBC1D3 using affinity purification combined with mass spectrometry an...
Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated α-tubulin. Despite the indispensable role of TTL in cell and organism development, its molecular mechanism of action is poorly understood. By solving crystal structures of TTL in complex with tubulin, we here demonstrate that TTL binds to the α and β subunits of tubulin and recognizes the curved confo...
Cortical microtubules (MTs) are evolutionarily conserved cytoskeletal components with specialized roles in plants, including regulation of cell wall biogenesis. MT functions and dynamics are dictated by the composition of their monomeric subunits, α- (TUA) and β-tubulins (TUB), which in animals and protists are subject to both transcriptional regulation and post-translational modifications (PTM...
Peloruside A and laulimalide are potent microtubule-stabilizing natural products with a mechanism of action similar to that of paclitaxel. However, the binding site of peloruside A and laulimalide on tubulin remains poorly understood. Drug resistance in anticancer treatment is a serious problem. We developed peloruside A- and laulimalide-resistant cell lines by selecting 1A9 human ovarian carci...
In recent years, the cultivation of tropical fruit crops has increased in Mediterranean basin, especially southern Italy. surveys conducted from 2014 to 2019 woody canker and shoot blight were observed on mango plants (cvs. Kent, Keitt, Sensation, Osteen, Kensington Pride) litchi Way Chee Kwai Mai Pink) cultivated Sicily. Botryosphaeriaceae Diaporthaceae consistently isolated symptomatic sample...
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