The highly stereoselective allylic alkylation of Morita-Baylis-Hillman carbonates with β-ketoesters catalysed by β-ICD is described. The corresponding products containing two adjacent quaternary and tertiary carbon centers were obtained in good yields with high diastereoselectivity (up to 10 : 1 dr) and enantioselectivity (up to 95% ee).

This work proposes the design of β-keto esters as antibacterial compounds. The was based on structure autoinducer bacterial quorum sensing, N-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). Eight ester analogues were synthesised with good yields and spectroscopically characterised, showing that compounds only present in their tautomer form. We carried out a computational analysis reactivi...

< p>In this communication, we have reported that the Pd(OAc)2–Et3SiH-DMF system promotes the microwave-assisted chemoselective reduction of aryl α,β-unsaturated esters in good yields. The protocol affords a convenient reduction of aryl-conjugated double bonds even in presence of other functional groups like esters, phenols, and ethers.

Palladium (II) coordination complexes catalyze the reaction of alcohols with ketones to yield ethers. During the catalytic cycle, the alcohol adds selectively to the β-carbon (anti-Markovnikov). In this work, mechanism and kinetics for the reaction of methanol with methyl vinyl ketone (MVK), being catalyzed by Pd, has been theoretically investigated in detail. Using quantum mechanical approach,...

• Pillar array columns was applied to α-keto acids analysis. α-Keto were derivatized with 1,2-diamino-4,5-methylenedioxybenzene for fluorescence detection. Four separated on pillar in 160 s. Three branched-chain human plasma samples successfully quantified. Branched-chain (BCKAs, namely, α-ketoisovaleric acid (KIV), α-ketoisocaproic (KIC), and α-keto-β-methylvaleric (KMV)) are related many dise...