The tumors of the external auditory canal are relatively rare. Among these tumors an osteoma is not common. Two cases of osteoma of the external auditory canal were reported. The patient, 26-year-old female, had a history of left-sided hearing impairment and w hard mass protruding from the posterior part of the left external canal. A stony hard mass almost completely occlu ded the left external...

Plasmaspheric densities have been observed previously to be higher in December than in June, with the ratio varying between 1.5 and 3.0 and with larger variations at lower œ shells. In order to search for the cause of the observed annual variations, we have modeled plasmaspheric density, using a time-dependent hydrodynamic model. On an L = 2 field line with geomagnetic longitude qual to 300 ø, ...

This paper examines whether lip protrusion is affected by initial strengthening of rounded vowels in French. Three speakers produced sentences containing the vowels /i, e, ɛ, a, y, ø, œ, u, o, ɔ/ at the beginning of different prosodic constituents: Intonational Phrase (IP), Accentual Phrase (AP) and Word (W). Using video and Qualisys motion capture data, three parameters (lip protrusion, area/l...

To evaluate the potential of memantine as a therapeutic agent for Huntington’s disease (HD) we have undertaken a series of in vitro, ex vivo and whole animal studies to characterize its pharmacokinetics (PK) and pharmacodynamics (PD) in rats and mice. Results from these studies will enable determination of memantine exposures needed to engage the related functional PD marker and help predict th...

Although open source projects have been subject to extensive study, their coordination processes are still poorly understood. Drawing on organization theory, this paper sets out to remedy this imbalance by showing that large-scale open source projects exhibit three main coordination mechanisms, namely standardization, loose coupling and partisan mutual adjustment. Implications in terms of elect...

Using sapje zebrafish which lack dystrophin, we have assessed both the quantitation of muscle damage in dystrophic fish, and the efficacy of the proteasomal inhibitor MG132 in reducing the dystrophic symptoms. Fourier analysis of birefringence patterns in normal and dystrophic fish was found to be a simple and reliable quantitative measure of muscle damage. MG132, as in mdx mouse, was found to ...

Background Since its initial detection in April 2009, the A/H1N1pdm influenza virus has spread rapidly in humans, with over 5,700 human deaths. However, little is known about the evolutionary dynamics of H1N1pdm and its geographic and temporal diversification. Methods Phylogenetic analysis was conducted upon the concatenated coding regions of whole-genome sequences from 290 H1N1pdm isolates sam...

In this modeling work, we explore the effectiveness of various age-targeted vaccination strategies to mitigate hospitalization and mortality from pandemic influenza, assuming limited vaccine supplies. We propose a novel adaptive vaccination strategy in which vaccination is initiated during the outbreak and priority groups are identified based on real-time epidemiological data monitoring age-spe...

Introduction and Methods: Pertussis has recently re-emerged in the United States. Timely surveillance is vital to estimate the burden of this disease accurately and to guide public health response. However, the surveillance of pertussis is limited by delays in reporting, consolidation and dissemination of data to relevant stakeholders. We fit and assessed a real-time predictive Google model for...

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (HTT) protein. The expression of mutant HTT in the baker’s yeast Saccharomyces cerevisiae recapitulates many of the cellular phenotypes observed in mammalian HD models. Mutant HTT aggregation and toxicity in yeast is influenced by the presence of the Rnq1p and Sup35p prions, as ...