β-thalassemia major (TM) is often accompanied by osteopenia or osteoporosis. Bisphosphonates have been used in the management of TM-induced bone loss. We report here the results of the long-term follow-up of our TM patients with osteoporosis who participated in a randomized, placebo-controlled trial with zoledronic acid (ZOL), the results of which at 12 months had been previously reported. Acco...

fosus-al-hekam is one of the most reliable mystical sources written by the well-known mohyeddin ibn-al-arabi. the purpose of the present article is to study different descriptions of fosus-al-hekam and presenting the meaning of hazaraat-e-khams (five attendances), its various parts, the opinions of different commentators and the similarities and differences in their comments. the author of the ...

Purpose: Clinical trials in early breast cancer have suggested that benefits of adjuvant bone-targeted treatments are restricted to womenwith establishedmenopause.We developedmodels thatmimic preand postmenopausal status to investigate effects of altered bone turnover on growth of disseminated breast tumor cells. Here, we report a differential antitumor effect of zoledronic acid (ZOL) in these ...

OBJECTIVE We aimed to assess the role of zoledronic acid (ZOL) on the risk of fracture and bone mineral density (BMD) in women with osteoporosis. METHODS A double-blind and placebo-controlled design was taken in our study. 327 patients who received an intravenous 5-mg infusion zoledronic acid at day 0, at 12 months were enrolled in treatment group, and the remaining 333 patients who received ...

New therapies are urgently needed against melanoma, one of the most aggressive tumors. Melanoma cells are resistant to the antifolate methotrexate (MTX), since MTX is taken up by the folate receptor-α (FRα), sequestered in melanosomes and exported out of the cell. The bisphosphonate zoledronic acid (ZOL) is active in several non-skeletal tumors; however, its antitumoral activity is hampered by ...

Background and aim: The Trabecular Bone Score (TBS) is an index of bone microarchitectural texture calculated from antero-posterior DXA scans of the lumbar spine (LS) that predicts fracture risk, independent of BMD. The aim of this study was to compare the effects of yearly intravenous zoledronate (ZOL) versus placebo (PLB) on LS BMD and TBS in postmenopausal women with osteoporosis. Materials ...

INTRODUCTION Local application of bisphosphonates has been proven to be safer than systemic administration to promote implant fixation. The objective of this study was to introduce such a simple, convenient and efficient method to enhance titanium (Ti) implant osseointegration in ovariectomized (OVX) rats. MATERIAL AND METHODS Twenty female Sprague-Dawley rats sequentially underwent bilateral...

The title compound, [Mn(C(8)H(4)N(8))(2)(H(2)O)(5)]·2H(2)O, is the fourth transition metal complex containing the 1,3-di(2H-tetra-zol-5-yl)benzene ligand to be structurally characterized. The Mn^II^ cation has a distorted octahedral coordination geometry. The 1,3-di(tetra-zol-5-yl)benzene ligand is planar. All H atoms bonded to O atoms participate in hydrogen bonds, which link the mol-ecules in...

Adult T-cell /lymphomaleukemia (ATLL) is caused by human T-cell lymphotropic virus type 1 (HTLV-1). Approximately 80% of ATLL patients develop humoral hypercalcemia of malignancy (HHM), a life-threatening complication leading to a poor prognosis. Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are important factors in the pathogenesis of HHM...

Among the main Spanish commercially available trademarks, we have selected a total of 25 samples of corn-based foods, which have the highest consume rate, to carry out the analysis of deoxynivalenol (DON), T-2 toxin, zearalenone (ZEA) and zearalenols (ZOL). The contents of mycotoxins were determined by gas chromatography with flame ionization detection, and those of ZEA were confirmed by HPLC w...