Abstract Protein metal-occupancy (metalation) in vivo has been elusive. To address this challenge, the available free energies of metals have recently determined from responses metal sensors. Here, we use these energy values to develop a metalation-calculator which accounts for inter-metal competition and changing metal-availabilities inside cells. We calculator understand function mechanism GT...

This paper reports on a series of five chiral Schiff base push-pull compounds derived from enantiomerically pure (1R,2R)-(?)-1,2-diaminocyclohexane. The NiII, CuII, ZnII and PdII complexes supported by ferrocene-containing unsymmetrically-substituted N2O2 quadridentate ligand were prepared via template reactions isolated in 74–87 % yields. A combination EA, IR, UV/vis 1H/13C{1H} NMR spectroscop...

Novel heteroleptic Zn II bis(dipyrrinato) complexes were prepared as intriguing emitters. With our tailor-made design, we achieved far-red emissive with a photoluminescence quantum yield up to 45% in dimethylsulfoxide and 70% toluene. This means that retain very intense emission also polar solvents, contrast their homoleptic counterparts, which for comparing the photophysical properties. It is ...

We show that the extinction of quasar absorbers increases exponentially with the logarithmic column density of any volatile metal (e.g. zinc), with a charateristic turning point above which the quasars are severely dimmed. We derive the relation between extinction, HI column density (NHI), metallicity (Z ≡ NZnII/NHI) and fraction of iron in dust [fFe(Z)] in Damped Lyman α (DLA) systems. We use ...

Many protein-protein interactions that play a central role in cellular processes involve α-helical domains. Consequently, there has been great interest in developing strategies for stabilizing short peptides in α-helical conformations toward the inhibition and interrogation of protein-protein interactions. Here, we show that tridentate Hybrid Coordination Motifs (HCMs), which consist of a natur...

The common structural feature of the title compounds, [Zn(C4H8NOS2)2(C5H5N)]·C5H5N (I) and [Zn(C5H10NOS2)2(C5H5N)]·C5H5N (II), which differ by having di-thio-carbamate N-bound methyl (I) and ethyl (II) groups, is the coordination of each ZnII atom by two non-symmetrically chelating di-thio-carbamate ligands and by a pyridine ligand; in each case, the non-coordinating pyridine mol-ecule is conne...