The first derivative of carboxypeptidase A, cobalt(III)(ethylenediamine-N,N’-diacetato)(arsanilazotyrosinato 248 (Co(III)(EDDA)(AA-CPA-Zn)), in which only the active site residue tyrosine 248 is blocked, has been shown to be completely peptidase-inactive while retaining esterase activity. Peptides are excellent inhibitors of esterase activity showing Ki values somewhat below the corresponding K...

Cadmium (Cd) is a known hepato- and nephrotoxic pollutant and zinc (Zn) metalloproteins are important targets of Cd. Hence, the administration of Zn may mitigate Cd toxic effects. However, the interaction of Cd and Zn has been little investigated in the brain. Previously, we reported a protective effect of Zn on mortality caused by Cd in rats. Here, we tested whether the protective effect of Zn...

The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg-1...

This study aimed to present the differences in corrosion properties and protective ability of two bi-layer systems obtained on low-carbon steel a model corrosive medium 5% NaCl solution. These newly developed consist Zn-Co (3 wt.%) or Zn-Ni (10 alloy coatings as under-layers very thin TiO2 sol-gel film top-layer. Scanning electron microscopy (SEM) is used for characterization surface morphology...

The first derivative of carboxypeptidase A, cobalt(III)(ethylenediamine-N,N’-diacetato)(arsanilazotyrosinato 248 (Co(III)(EDDA)(AA-CPA-Zn)), in which only the active site residue tyrosine 248 is blocked, has been shown to be completely peptidase-inactive while retaining esterase activity. Peptides are excellent inhibitors of esterase activity showing Ki values somewhat below the corresponding K...

Zn, K, and Cu effects on the structure and surface area and on the reduction, carburization, and catalytic behavior of Fe–Zn and Fe oxides used as precursors to Fischer–Tropsch synthesis (FTS) catalysts, were examined using X-ray diffraction, kinetic studies of their reactions with H2 or CO, and FTS reaction rate measurements. Fe2O3 precursors initially reduce to Fe3O4 and then to metallic Fe (...

Vertebrate GATA proteins regulate processes that are vital to development, and each possesses two tandem GATA finger domains: an N-terminal GATA finger and a C-terminal GATA finger. These GATA fingers require Zn(2+) to fold, to bind DNA recognition elements, and to regulate transcription. While the GATA-1 C-terminal finger is necessary and sufficient to bind to single GATA DNA sites, the N-term...

introduction: zinc (zn) is cofactor of more than 300 enzymes and is needed for growth, dna synthesis, immunity and other important cellular processes (wood, 2000). cobalt (co) has been demonstrated to be an essential nutrient for ruminants and is required by ruminal microorganisms for the synthesis of vitamin b12 (mcdowell, 2000). selenium is an integral component of the enzyme glutathione pero...