Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrate or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of zidovudine, an antiretroviral drug, were prepared using different superdisintegrants viz. Crospovidone (PPXL), Crosscarmellose sodium (Ac-di-sol) and sodium starch glycollate by direct compression metho...

BACKGROUND With the advent of effective antiretroviral therapy, the care of patients with human immunodeficiency virus infection became more like that of other chronic diseases. Diabetes mellitus can also occur as one of the chronic illnesses affecting patients with human immunodeficiency virus infection. We report a case of newly developed diabetes mellitus in a patient with human immunodefici...

Zidovudine (AZT) is a nucleoside analog, a reverse transcriptase inhibitor (NRTI) and a type of antiretroviral drug used for the treatment of HIV/AIDS. The administration of zidovudine to the wistar albino rats showed an increase in erythrocyte fragility as can be seen from figure 1. There were significant (p<0.05) increases in serum Aspartate aminotranseferase (AST) activity, and GlutathioneSt...

OBJECTIVES Treatment of HIV-infected patients is associated with early onset of aging-related comorbidities. Some of the adverse effects of antiretroviral therapy have been attributed to the mitochondrial toxicity of nucleoside reverse transcriptase inhibitors (NRTI), and it is of note that mitochondrial dysfunction and oxidative stress are involved in the aging processes. In this regard, we ex...

Hematopoietic dysfunction with peripheral cytopenias is a common complication of human immunodeficiency virus (HIV) infection. Symptomatic anemia is the most common cytopenia and occurs in the presence and absence of myelosuppressive drug therapy such as zidovudine. Drug-induced neutropenia and immune thrombocytopenia are also frequent and occur in up to 50% of acquired immunodeficiency syndrom...

OBJECTIVES HIV-1 reverse transcriptase (RT) mutations associated with antiviral drug resistance have been extensively characterized in the enzyme polymerase domain. Recent studies, however, have verified the involvement of the RT C-terminal domains (connection and RNase H) in drug resistance to RT inhibitors. In this work, we have characterized the correlation of recently described C-terminal d...

We report two cases of thrombotic thrombocytopenic purpura (TTP) in advanced stage HIV-positive patients (CD4+ < 0.05 x 10(9)/L). Clinical symptoms were relevant, but their course was not fulminant; the two patients responded to different therapies (plasma or plasma plus plasmapheresis, and steroids), showing rapid improvement in symptoms. One patient remained asymptomatic with zidovudine only,...