In this paper we present the ongoing experiments at ATOMKI related to our systematic γ-process studies. These studies are intended to enlarge the limited experimental database from α-induced reactions on nuclei in the heavier mass range of the γ-process. In all presented cases the activation method was used. The details of the cross section measurements and preliminary results on In(α,n)Sb, In(...

Mature af3and yb T cells arise from a common precursor population in the thymus. Much debate has focused on the mechanism of T cell lineage choice made by these multi-potential precursor cells. It is widely believed that the decision of these precursor cells to commit to the yb or af3 T cell lineages is regulated primarily by a specific instrctive signal relayed through the appropriate T cell r...

Oxyfluoride glasses doped with 2, 5, 8, 12, 16 and 20 mol% of ytterbium (Yb(3+)) ions have been prepared by the conventional melt-quenching technique. Their optical, thermal and thermo-mechanical properties were characterized. Luminescence intensity at 1020 nm under laser excitation at 920 nm decreases with increasing Yb(3+) concentration, suggesting a decrease in the photoluminescence quantum ...

Clusterin is a stress-activated, cytoprotective chaperone that confers broad-spectrum treatment resistance in cancer. However, the molecular mechanisms mediating CLU transcription following anticancer treatment stress remain incompletely defined. We report that Y-box binding protein-1 (YB-1) directly binds to CLU promoter regions to transcriptionally regulate clusterin expression. In response t...

We report the near to middle infrared luminescence and energy transfer process of Er(3+)/Yb(3+) co-doped fluorotellurite glasses under 980, 1550 and 800 nm excitations, respectively. Using a 980 nm laser diode pump, enhanced 1.5 and 2.7 μm emissions from Er(3+):I13/2→(4)I15/2 and I11/2→(4)I13/2 transitions are observed, in which Yb(3+) ions can increase pumping efficiency and be used as energy ...

BACKGROUND Y-box binding protein 1 (YB-1) belongs to the cold shock domain protein family involved in transcription and translation. We conducted a meta-analysis of the association between YB-1 expression and the survival and clinicopathological features in NSCLC. METHODS PubMed and Embase were searched to identify studies that evaluated the YB-1 expression (by immunohistochemistry) and overa...

Clusterin is a stress-activated, cytoprotective chaperone that confers broad-spectrum treatment resistance in cancer. However, the molecular mechanisms mediating CLU transcription following anticancer treatment stress remain incompletely defined. We report that Y-box binding protein-1 (YB-1) directly binds to CLU promoter regions to transcriptionally regulate clusterin expression. In response t...

Hanahan and Weinberg have proposed the 'hallmarks of cancer' to cover the biological changes required for the development and persistence of tumours [Hanahan and Weinberg (2011) Cell 144, 646-674]. We have noted that many of these cancer hallmarks are facilitated by the multifunctional protein YB-1 (Y-box-binding protein 1). In the present review we evaluate the literature and show how YB-1 mod...

The observed limiting fragmentation of charged particle distributions in heavy ion collisions is difficult to explain as it does not apply to the proton spectrum itself. On the other hand, string percolation provides a mechanism to regenerate fast particles, eventually compensating the rapidity shift (energy loss) of the nucleons. However a delicate energy-momentum compensation is required, and...

Both the TATA and CCAAT boxes are widespread promoter elements and their binding proteins, TBP and NF-Y, are extremely conserved in evolution. NF-Y is composed of three subunits, NF-YA, NF-YB and NF-YC, all necessary for DNA binding. NF-YB and NF-YC contain a putative histone-like motif, a domain also present in TBP-associated factors (TAFIIs) and in the subunits of the transcriptional represso...