Rats use their large facial whiskers to discriminate the spatial features of objects. Despite numerous electrophysiological recording studies in the central trigeminal whisker representations that document neurons tuned to the direction of whisker deflection, there is no behavioral evidence to date that rats can use their whiskers to discriminate between object orientations. In the present stud...

• hnRNPLL is abundantly expressed in immune memory T lymphocytes and the brain. hypomorphism thunder mice ( hnrpll ) causes cell deficits. show enhanced tail suspension immobility reduced learning/memory. subtle prepulse intensity-related inhibition. No changes forced swim test, plus-maze, startle or exploratory habituation. Heterogeneous nuclear ribonuclear protein l -like (hnRNPLL) an RNA bin...

This paper proposes a context-aware decision making framework for a maze solving robot. The proposed architecture utilizes a fuzzy integral based decision making scheme to select the best behavior according to the current environmental context of the robot. The simulation results show that despite having no prior information about the arrangement of the maze, the proposed cognitive architecture...

Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein leading to cognitive and/or motor dysfunction. To understand the relationship between tau pathology and behavioral impairments, we comprehensively assessed behavioral abnormalities in a mouse tauopathy model expressing the human P301S mutant tau protein in the early stage of disease to detect i...

abstract background and objective: alzheimer’s disease (ad) is a weakening neurodegenerative disorder typified by increased b-amyloid (ab) deposition and neuronal dysfunction causing to impaired learning and memory. among proposed risk factors, induced oxidative stress is a main cause for incidence of the disease. the aim of this study was to determine the effects of the rosmarinic acid on lear...

This study examined the effects of social housing manipulations on bodyweight, corticosterone levels, and performance of T-maze alternation in male CD-1 mice. Males that adopted a dominant social rank were heavier than those that adopted a subordinate social rank. Dominant males also had lower corticosterone concentrations than the subordinates. However, there was little to suggest that these p...

The elevated plus maze test is a rodent model of anxiety that is used extensively in the discovery of novel anxiolytic agents and to investigate the psychological and neurochemical basis of anxiety. The model is based on Montgomery's 1 observation that rats spent less time exploring the 'open' arms of a novel 'Y'-shaped elevated maze than an enclosed arm. The elevated plus maze used today 2 is ...

In the picturesque maze generation problem, we are given a rectangular black-and-white raster image and want to randomly generate a maze in which the solution path fills up the black pixels. While a simple formulation of the problem faces with NP-hardness, the proposed method generates such a maze in polynomial time by appropriately changing the formulation itself. Therefore, the algorithm itse...

Objective: Parkia biglobossa stem bark decoction is a popular medicinal plant preparation used as calming agent for tensed patients in traditional medicine. The aim of this study was to evaluate the effects of aqueous stem bark extract of Parkia biglobossa (AEPB) and its active fraction AEPBF3 on anxiety, spontaneous alternation behavior, and locomotor activity. The open field apparatus was use...

When Richard Morris devised his water maze in 1981(7), most behavioral work was done in rats. However, the greater understanding of mouse genetics led to the mouse becoming increasingly important. But researchers found that some strains of mutant mice were prone to problems like passively floating or diving when they were tested in the Morris water maze(11). This was unsurprising considering th...