BACKGROUND The production process for the current influenza vaccine takes about 6 months and its antigenic composition must be modified annually. In the attempt towards developing influenza vaccine production that would be faster, safer and cheaper we engineered an influenza vaccine in which multiple copies of hemagglutinin (HA) would be delivered by a vector, adenovirus dodecahedron (Ad Dd). D...

The present study was carried out to estimate phenotypic and genetic parameters of Red Chittagong Cattle (RCC) for growth traits. Means of birth weight (BW), three month weight (3MW), six month weight (6MW), weaning weight (WW), nine month weight (9MW) and yearling weight (YW) were 15.74, 31.48, 45.33, 57.00, 60.91 and 76.18 kg respectively. Sex significantly (p<0.001) differed BW of calves but...

The epithelial Na+ channel (alphabetagammaENaC) regulates salt and fluid homeostasis and blood pressure. Each ENaC subunit contains a PY motif (PPXY) that binds to the WW domains of Nedd4, a Hect family ubiquitin ligase containing 3-4 WW domains and usually a C2 domain. It has been proposed that Nedd4-2, but not Nedd4-1, isoforms can bind to and suppress ENaC activity. Here we challenge this no...

We characterized the bacterial populations in surface water receiving effluent from an oxytetracycline (OTC) production plant. Additional sampling sites included the receiving river water 5 km upstream and 20 km downstream from the discharge point. High levels of OTC were found in the wastewater (WW), and the antibiotic was still detectable in river water downstream (RWD), with undetectable lev...

The levels and congener patterns of HBCDs (hexabromocyclododecanes) and PFCs (perfluorinated compounds) were determined in filter-feeding molluscs collected in 2008 and 2010 along the coasts of mainland France. α-HBCD and PFOS (perfluorooctane sulfonate) were detected in all samples, revealing widespread contamination of the coastal environment by these emerging contaminants. The spatial distri...

Although a number of recent studies have focused on the existence of a non-negligible sire contemporary group interaction effect (s) affecting the estimation of genetic parameters for maternally influenced traits in beef cattle, the assessment and interpretation of this effect using field data remains poorly understood. In this study 27,639 records of both birth weight (BW) and weaning weight (...

OBJECTIVE To assess the long-term crossover (CO) rate in men undergoing watchful waiting (WW) as a primary treatment strategy for their asymptomatic or minimally symptomatic inguinal hernias. BACKGROUND With an average follow-up of 3.2 years, a randomized controlled trial comparing WW with routine repair for male patients with minimally symptomatic inguinal hernias led investigators to conclu...

Fate and transport studies of silver nanoparticles (AgNPs) discharged from urban wastewaters containing effluent organic matter (EfOM) into natural waters represent a key knowledge gap. In this study, EfOM interfacial interactions with AgNPs, and their aggregation kinetics were investigated by atomic force microscopy (AFM) and time-resolved dynamic light scattering (TR-DLS), respectively. Two w...

BACKGROUND Observation is underutilized among men with localized, low-risk prostate cancer. OBJECTIVE To assess the costs and benefits of observation versus initial treatment. DESIGN Decision analysis simulating treatment or observation. DATA SOURCES Medicare schedules, published literature. TARGET POPULATION Men aged 65 and 75 years who had newly diagnosed low-risk prostate cancer (pro...

This letter reports the observation of photon-induced production W-boson pairs, γγ→WW. The analysis uses 139 fb−1 LHC proton–proton collision data taken at s=13 TeV recorded by ATLAS experiment during years 2015–2018. measurement is performed selecting one electron and muon, corresponding to decay diboson system as WW→e±νμ∓ν final state. background-only hypothesis rejected with a significance w...