نتایج جستجو برای: wnt

تعداد نتایج: 22773  

Journal: :Diagnostyka 2022

1. Frączek J, Wojtyra M. Kinematyka układów wieloczłonowych. WNT Warszawa, 2008. Google Scholar

2016
Yaohui Chen Yu Li Jianfei Xue Aihua Gong Guanzhen Yu Aidong Zhou Kangyu Lin Sicong Zhang Nu Zhang Cara J Gottardi Suyun Huang

A key step of Wnt signaling activation is the recruitment of b-catenin to the Wnt target-gene promoter in the nucleus, but its mechanisms are largely unknown. Here, we identified FoxM1 as a novel target of Wnt signaling, which is essential for b-catenin/TCF4 transactivation. GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. Wnt signaling activation in...

Journal: :The Biochemical journal 1998
T C Dale

The Wnt genes encode a large family of secreted polypeptides that mediate cell-cell communication in diverse developmental processes. The loss or inappropriate activation of Wnt expression has been shown to alter cell fate, morphogenesis and mitogenesis. Recent progress has identified Wnt receptors and components of an intracellular signalling pathway that mediate Wnt-dependent transcription. T...

Journal: :EMBO reports 2015
Ailine Stolz Kim Neufeld Norman Ertych Holger Bastians

Wnt signaling stimulates cell proliferation by promoting the G1/S transition of the cell cycle through β-catenin/TCF4-mediated gene transcription. However, Wnt signaling peaks in mitosis and contributes to the stabilization of proteins other than β-catenin, a pathway recently introduced as Wnt-dependent stabilization of proteins (Wnt/STOP). Here, we show that Wnt/STOP regulated by basal Wnt sig...

Journal: :The Journal of Cell Biology 2003
Gilbert Weidinger Randall T. Moon

Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that "noncanonical" Wnt signaling inhibits the "canonical" Wnt/beta-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of beta-catenin, whereas Topol et al. (2003) report that cho...

Journal: :Acta biochimica et biophysica Sinica 2008
Xi Chen Jun Yang Paul M Evans Chunming Liu

Since the first Wnt gene was identified in 1982, the functions and mechanisms of Wnt signaling have been extensively studied. Wnt signaling is conserved from invertebrates to vertebrates and regulates early embryonic development as well as the homeostasis of adult tissues. In addition, both embryonic stem cells and adult stem cells are regulated by Wnt signaling. Deregulation of Wnt signaling i...

Journal: :The Journal of biological chemistry 2013
Vipul Chitalia Sowmya Shivanna Jordi Martorell Rosana Meyer Elazer Edelman Nader Rahimi

Regulation of transcriptionally active nuclear β-catenin during the Wnt-on phase is crucial to ensure controlled induction of Wnt target genes. Several ubiquitin E3 ligases are known to regulate cytosolic β-catenin during the Wnt-off phase, but little is known about the fate of active nuclear β-catenin in the Wnt-on phase. We now describe ubiquitination of active β-catenin in the Wnt-on phase b...

2011
Rui Wang Joumana Ahmed Guoqing Wang Ibrahim Hassan Yael Strulovici-Barel Neil R. Hackett Ronald G. Crystal

BACKGROUND The Wnt pathway mediates differentiation of epithelial tissues; depending on the tissue types, Wnt can either drive or inhibit the differentiation process. We hypothesized that key genes in the Wnt pathway are suppressed in the human airway epithelium under the stress of cigarette smoking, a stress associated with dysregulation of the epithelial differentiated state. METHODOLOGY/PR...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Miao Cui Natnaree Siriwon Enhu Li Eric H Davidson Isabelle S Peter

Wnt signaling affects cell-fate specification processes throughout embryonic development. Here we take advantage of the well-studied gene regulatory networks (GRNs) that control pregastrular sea urchin embryogenesis to reveal the gene regulatory functions of the entire Wnt-signaling system. Five wnt genes, three frizzled genes, two secreted frizzled-related protein 1 genes, and two Dickkopf gen...

Journal: :Molecular cancer research : MCR 2011
Chen-Yin Ou Melissa J LaBonte Philipp C Manegold Alex Yick-Lun So Irina Ianculescu Daniel S Gerke Keith R Yamamoto Robert D Ladner Michael Kahn Jeong Hoon Kim Michael R Stallcup

Aberrant activation of Wnt/β-catenin signaling, resulting in the expression of Wnt-regulated oncogenes, is recognized as a critical factor in the etiology of colorectal cancer. Occupancy of β-catenin at promoters of Wnt target genes drives transcription, but the mechanism of β-catenin action remains poorly understood. Here, we show that CARM1 (coactivator-associated arginine methyltransferase 1...

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