OBJECTIVE Evaluate ustekinumab, an anti-interleukin (IL)-12 and IL-23 antibody, effects on radiographic progression in psoriatic arthritis (PsA). METHODS We conducted preplanned integrated analyses of combined radiographic data from PSUMMIT-1 and PSUMMIT-2 phase 3, randomised, controlled trials. Patients had active PsA despite prior conventional and/or biologic disease-modifying antirheumatic...

Turkeys from two BW groups (which averaged 11.8 and 12.9 kg, Normal and Heavy, respectively) were photostimulated at either 29 or 31 wk of age to determine what effects age-associated changes in hen carcass characteristics, egg weight, and egg components have on subsequent poult weight at hatching during the first 10 wk of production. Carcass measurements were determined from a subsample of hen...

To determine events that transpire during the earliest stages of human T cell development, we have studied fetal tissues before (7 wk), during (8.2 wk), and after (9.5 wk to birth) colonization of the fetal thymic rudiment with hematopoietic stem cells. Calculation of the approximate volumes of the 7- and 8.2-wk thymuses revealed a 35-fold increase in thymic volumes during this time, with 7-wk ...

Silk fibroin (SF) is a natural, degradable, fibrous protein that is biocompatible, is easily processed, and possesses unique mechanical properties. Another natural material, wool keratose (WK), is a soluble derivative of wool keratin, containing amino acid sequences that induce cell adhesion. Here, we blended SF and WK to improve the poor electrospinability of WK and increase the adhesiveness o...

wk). Birds grew 819 g during the 4 to 8wk period (CV = 15.0 %), as compared to only 389 g in the 8 to 12 wk period (CV = 15.3 %). Although there was no difference in the variation on a population basis, drastic changes are apparent when data was expressed in relative gains. The variation for relative gains ranged from a low of 17.2 % in the 4 to 8 wk period to a high of 41.0 % in the 16 to 18 w...

[wk 44] Wed 2 Nov 11 Lec 2: Pairwise alignment II JH Asn 1: Pairwise Alignment [wk 45] Mon 7 Nov 11 Lec 3: Substitution matrices SA, PB Questions hour (QH) [wk 45] Wed 9 Nov 11 Lec 4: Multiple Sequence JH QH Alignment I [wk 46] Mon 14 Nov 11 Lec 5: Multiple Sequence JH QH Alignment II [wk 46] Wed 16 Nov 11Lec 6: Markov models JH Asn 2: HMM; Deadline Asn 1 [wk 47] Mon 21 Nov 11 Lec 7: Hidden Mar...

Colorectal Cancer (CRC) is defined as colon and rectum cancer among the major causes of mortality in developed Countries. Tarantula cubensis alcoholic extract (TCAE) Nerium oleander distillate (NOD) are reported to have anticancer antioxidative activity. In this study, it was aimed research impact on cell proliferation markers TCAE NOD given simultaneously experimental cancer. A total 24 rats, ...

Abstract Background Inconsistent associations between egg consumption and cardiovascular disease (CVD) risk have been observed in previous studies. This study aims to longitudinally investigate the association altered of arterial stiffness, a major pre-clinical pathogenic change CVD, which was assessed by brachial-ankle pulse wave velocity (baPWV). Methods A total 7315 Chinese participants from...

Background and Purpose: Although it has been reported that the amount of alcohol consumption a J-shaped association with ischemic stroke, is unclear whether differences in drinking patterns affect this relationship. We aimed to clarify impact on stroke midlife. Methods: used data from National Health Insurance Service-National Sample Cohort, which large-sized, standardized population cohort Kor...

We have investigated the effect of increasing numbers of hyperthermia fractions given at 7-day intervals, with or without fractionated radiotherapy, on tumor cure, tumor growth, and cell survival after in vivo or in vitro heat. The murine RIF tumor was treated by capacitive radiofrequency hyperthermia at 44.0 degrees C for 20 min for one to five treatments at weekly intervals (1-5 wk D1). Singl...