ackground: Catechol-O-methyltransferase (COMT) is a strong candidate gene for schizophrenia and cognitive functions disrupted n this disorder. This report examines the relation of COMT genotypes to performance on a battery of working memory tests differing n the cognitive operations to be performed on the material. ethods: A large sample of 402 healthy adults were tested on four working memory ...

There has been a long-standing debate in the fields of philosophy and cognitive science surrounding the relationship of language to cognition, but the exact nature of this relationship is still unclear (Sokolov, 1968/1972). In the current study, we explored the role of language in one aspect of cognition, namely problem solving, by administering the Wisconsin Card Sorting Test (WCST) to stroke ...

AIM The aim of the present study was twofold: 1. to compare the efficacy of three antipsychotics (ziprasidone, olanzapine and perazine) in schizophrenia 2. to compare the improvement in cognitive functioning between groups treated with the three different neuroleptics. METHOD A total of 58 Caucasian patients diagnosed with paranoid schizophrenia were recruited into the study group. We used th...

Motor symptoms in Gilles de la Tourette syndrome (GTS) have been related to changes in frontostriatal brain networks. These changes may also give rise to alterations in cognitive flexibility. However, conclusive evidence for altered cognitive flexibility in patients with GTS is still lacking. Here, we meta-analyzed data from 20 neuropsychological studies that investigated cognitive flexibility ...

Children with either fetal alcohol spectrum disorder (FASD) or attention-deficit/hyperactivity disorder (ADHD) display deficits in attention and executive function (EF) and differential diagnosis of these two clinical groups may be difficult, especially when information about prenatal alcohol exposure is unavailable. The current study compared EF performance of three groups: children with heavy...

Employment provides schizophrenic patients with a positive identity and hope. Cognitive impairments have been suggested to slow down the progress in work rehabilitation. The purpose of this study was to investigate the efficacy and effectiveness of VR as a cognitive intervention for enhancing vocational outcomes. 95 inpatients with schizophrenia were randomly assigned to a virtual reality-based...

This study aimed to explore non-verbal executive processes in simultaneous interpreters. Simultaneous interpreters, bilinguals without any training in simultaneous interpreting, and control monolinguals performed the Wisconsin card sorting task (WCST; Experiment 1) and the Simon task (Experiment 2). Performance on WCST was thought to index cognitive flexibility while Simon task performance was ...

Early functional neuroimaging studies of tasks evaluating executive processes, such as the Wisconsin card sorting task (WCST), only assessed trials in blocks that may contain a large amount of different cognitive processes. More recently, we showed using event-related fMRI that the dorsolateral prefrontal cortex (DL-PFC) significantly increased activity during feedback but not matching periods ...