BACKGROUND Pressure contour analysis is commonly used to estimate cardiac performance for patients suffering from cardiovascular dysfunction in the intensive care unit. However, the existing techniques for continuous estimation of stroke volume (SV) from pressure measurement can be unreliable during hemodynamic instability, which is inevitable for patients requiring significant treatment. For t...

This paper presents an experimental study of three bioreactor configurations. The bioreactor is intended to be used for the development of tissue-engineered heart valve substitutes. Therefore it must be able to reproduce physiological flow and pressure waveforms accurately. A detailed analysis of three bioreactor arrangements is presented using mathematical models based on the windkessel (WK) a...

Techniques for Studying Arterial Elastic Properties To the Editor: I applaud the effort of Rietzchel and colleagues1 to compare two techniques in wide use for studying arterial elastic properties. This is a study long in need of performance because of the controversial claims in the literature relating to the theory of systolic and diastolic waveform analysis. As we had anticipated and predicte...

The application of cardiac catheterization to the study of the human circulation (Forssmann, 1929; Cournand and Ranges, 1941) provided a new technique for obtaining information about the pulmonary circulation and also for the study of the physiological effects of congenital heart disease (Bing et al., 1947a; Dexter et al., 1947b; Cournand et al., 1949). Extensive studies have been made in which...

In this work, a lumped-parameter Windkessel model of the cardiovascular system that simulates biomechanical parameters human physiology is presented. The object-oriented platform provided by MATLAB-based modeling environment SIMSCAPE employed to compute blood pressures and flows in each heart chamber at various sites vascular tree. hydraulic domain allows determination hemodynamics intuitively ...

In this study, a patient-specific carotid artery model was analyzed with an open source program foam-extend. The research includes the effect of arterial wall deformation by fluid-structure analysis. Pulsatile velocity cycle is trained for 144 patients different hemodynamic parameters, machine learning algorithm using blood flow measured from 337 points artery. Data used training obtained in li...

We developed a novel patient-specific computational model for the numerical simulation of ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This reproduces activity both sinus rhythm (SR) and tachycardia (VT). The presence scars, grey zones non-remodeled regions myocardium is accounted by introduction spatially heterogeneous coefficient 3D model. firstly coupled 2-ele...