In medicine, it is encouraging when research yields results consistent with our understanding of the operative mechanisms, especially when there is a direct potential impact on clinical practice. Chan et al. have provided us with such a result and a clear message. The 2-year follow-up in the Pacing to Avoid Cardiac Enlargement (PACE) trial confirms that chronic right ventricular (RV) pacing in ...

The Sicilian Gambit: an opening move that loses the game? The Sicilian Gambit is the title of a review article on antiarrhythmic drug therapy published simultaneously in the European Heart Journal and Circulation in 1991 1 ' 1. The rather peculiar name is a reference to the Queen's Gambit (an opening move in chess) and the fact that the article, considered by the authors as an 'opening move' in...

Bundle branch block is a common cause of a widened QRS complex, and, as indicated in Table 1, different mechanisms may be responsible. Three are rate related and one is based upon retrograde invasion into the bundle branch. Those four mechanisms lead to the intermittent appearance of a bundle branch block pattern. Most commonly, bundle branch block is continuously present, so-called fixed bundl...

OBJECTIVE There is limited information on mirtazapine overdose, but cases of severe effects (seizures, serotonin toxicity and coma) have been reported. We aimed to investigate the clinical effects and complications of mirtazapine overdose. METHODS This was an observational case series of mirtazapine overdoses (> 120 mg) identified from admissions to a toxicology unit between January 1987 and ...

We present a new threat based search algorithm that outperforms other threat based search algorithms and selective knowledge-based for open life and death problem solving in the game of Go. It generalizes the Iterative Widening algorithm which consists in iteratively increasing the threat searched at the root. The main idea of Generalized Widening is to perform Iterative Widening at all max nod...

We study the problem of an efficient and precise sharing analysis of (constraint) logic programs. After recognizing that neither plain Sharing nor its non-redundant (but equivalent) abstraction scale well to real programs, we consider the domain proposed by C. Fecht [11, 12]. This domain consists of a combination of Pos with a quite weak abstraction of Sharing. While verifying that this domain ...