Introduction. Progressive supranuclear palsy (PSP) is the second most common cause of neurodegenerativeparkinsonism after idiopathic Parkinson’s disease (PD) [1]. A different ante-mortem distribution of white matter (WM) damage may exist in PD and PSP patients, which might be helpful in the diagnostic work-up of these patients [2]. In this study, we investigated microstructural changes of WM in...

Purpose To identify the focal and diffuse white matter (WM) pathology measures that are related to respectively whole brain, deep and cortical gray matter (GM) atrophy in long-standing multiple sclerosis (MS). Materials and methods The institutional review board approved the study; all subjects gave written informed consent. MRI was performed at 3T in 208 MS patients with long-standing disease ...

Frontotemporal lobar degeneration (FTLD) has a high frequency of genetic forms; the 2 most common are GRN (progranulin) and C9ORF72 mutations. Recently, our group reported extensive white matter (WM) lesions in 4 patients with FTLD caused by GRN mutation, in the absence of noteworthy cardiovascular risk factors,(1) in line with other studies in GRN mutation carriers.(2,3) Here we compared the c...

In a cohort of community-recruited elderly subjects with normal cognition at initial evaluation, we found that baseline fornix white matter (WM) microstructure was significantly correlated with early volumetric longitudinal tissue change across a region of interest (called fornix significant ROI, fSROI), which overlaps circuits known to be selectively vulnerable to Alzheimer's dementia patholog...

Diffusion tensor imaging (DTI) studies have provided evidence of widespread white matter (WM) abnormalities in schizophrenia. Although these abnormalities appear clinically significant, the relationship to specific clinical symptoms is limited and heterogeneous. This study examined the association between WM microstructure and the severity of the five main DSM-5 schizophrenia symptom dimensions...

BACKGROUND Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated w...

Diffusion mri (dmri) is the only method that allows in vivo segmentation of white matter (wm) fasciculi and assessment of their integrity, based on the water diffusion anisotropy caused by highly ordered bundles of axons [5, 6]. It can therefore be used to study wm decline: loss of integrity and tract thinning. Their disambiguation given the mri data is not trivial. We show that it is possible ...

Introduction. Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis is highly refractory to clinical treatment. MRI voxel-based morphometry (VBM) of T1-weighted images has revealed a widespread pattern of gray matter (GM) and white matter (WM) atrophy in MTLE. Few studies have investigated the role of T2-weighted images in revealing WM atrophy using VBM. Objectives. To comp...

OBJECTIVES Conventional MRI at term age has been reported to be superior to cranial ultrasound (cUS) in detecting white matter (WM) abnormalities and predicting outcome in preterm infants. However, in a previous study cUS was performed during the first 6 weeks only and not in parallel to MRI at term age. Therefore, the aim of the present work was to study brain injuries in preterm infants perfo...

Individuals with psychosis have an increased risk of committing acts violence. Providing neurobiological evidence for the extent to which violence in is driven by psychotic symptoms and/or antisocial traits could important clinical and legal implications. White matter (WM) abnormalities been reported individuals those traits. However, it not clear if WM violent (violent PSY) resemble previously...