A novel 2-D coordination polymer constructed from high nuclearity nanosized Ho48 clusters was synthesised and structurally characterized using single-crystal X-ray analysis. The Ho48 cluster core with a charming waist drum-like structure was templated by CO3(2-) ions, and bridged by Ho-N bonds to get a 2-D coordination polymer.

Methods The safety of RPL554 0.003 and 0.009 mg/kg was evaluated in 18 healthy males (age 18-41 years; weight 58-90 kg; height 168-196 cm; BMI 18-29 kg/m) in a randomised, double-blind study. For each dose group, 6 subjects inhaled RPL554 and 3 placebo. Study medication was administered by a calibrated electronic nebuliser and oronasal mask. Subsequently, RPL554 0.009 and 0.018 mg/kg were evalu...

BACKGROUND Obesity is a risk factor for left ventricular (LV) hypertrophy and excess cardiovascular disease and mortality. Substantial weight loss is associated with a decrease in cardiovascular mortality. Using volumetric cardiovascular magnetic resonance (CMR) imaging, we studied changes in cardiac anatomy and systolic function in women undergoing substantial weight loss in a university hospi...

OBJECTIVE To evaluate the influence of dietary intake during gestation on postpartum weight retention. METHODS A total of 82 healthy pregnant women who began prenatal care at public healthcare services in the Municipality of São Paulo (Southeastern Brazil) between April and June 2005 were followed up. Weight and height were measured in the first interview (up to 16 weeks of gestation) and the...

OBJECTIVE A weight loss maintenance trial involving weight loss prior to randomization is challenging to implement due to the potential for dropout and insufficient weight loss. We examined rates and correlates of non-initiation, dropout, and insufficient weight loss during a weight loss maintenance trial. METHODS The MAINTAIN trial involved a 16-week weight loss program followed by randomiza...

BACKGROUND There is a paucity of data available regarding the dosing of antimicrobials in obesity. However, data are available demonstrating that vancomycin should be dosed on the basis of actual body weight. METHODS This study was conducted at 2 tertiary care medical centers that did not have pharmacy-guided vancomycin dosing programs or other institutional vancomycin dosing policies or prot...

P a t i e n t s 300 patients (mean age 61 y, 82% men) who were > 18 years of age, had had the first symptoms of MI within 12 hours before enrollment, and had ST-segment elevation of > 1 mm in ≥ 2 contiguous electrocardiographic leads. Exclusion criteria were bleeding diathesis; administration of thrombolytic agents for the current episode; neoplasm; recent stroke; uncontrolled hypertension; rec...

We developed monoclonal antibodies against Drosophila topoisomerase II and studied the intracellular forms and the in vivo and in vitro proteolytic degradation of the enzyme. In purified enzyme preparations polyclonal sera and monoclonal antibodies recognized several polypeptides in the 170-132 kD molecular weight range. In vivo, however, the pattern was much simpler. In Drosophila embryos, pup...

P a t i e n t s 840 patients (median age 58 y, 82% men) with symptoms of MI for ≤ 6 hours. Exclusion criteria were known bleeding disorders or contraindication to fibrinolysis, severe renal or hepatic insufficiency, aortofemoral bypass or hampered femoral artery access, cardiogenic shock, history of coronary artery bypass graft surgery, current oral anticoagulant treatment, or expected duration...