OBJECTIVE This study was undertaken to evaluate the neuroprotective activity of Wedelia calendulacea against cerebral ischemia/reperfusion induced oxidative stress in the rats. MATERIALS AND METHODS The global cerebral ischemia was induced in male albino Wistar rats by occluding the bilateral carotid arteries for 30 min followed by 1 h and 4 h reperfusion. At various times of reperfusion, the...

Wedelia trilobata (L.) Hitch is a member of the family Asteraceae, with attractive yellow flowers borne singly at the end of each stem. The work was conducted to investigate the antioxidant, antimicrobial and DNA protecting ability of the methanol extract of W. trilobata flower. Antioxidant properties were assessed by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and 2,2'-azino-bis 3thylbenzthiazoline-...

For centuries, plants have been used to treat several diseases worldwide including wound healing, and are still playing a major role in healthcare systems in many developing countries. Wound is defined as the disruption of the cellular and anatomic continuity of a tissue and may be produced by physical, chemical, thermal, microbial or immunological insult to the tissues. The process of wound he...

BACKGROUND Wedelia chinensis is traditionally used as a hepatoprotective herb in Taiwan. The aim of this study was to evaluate the neuroprotective potential of W. chinensis. METHODS An ethyl acetate extract of W. chinensis (EAW) was prepared and analyzed by HPLC. The neuroprotective potential of EAW was assessed by tert-butylhydroperoxide (t-BHP)-induced damage in PC12 cells and D-galactose-i...

BACKGROUND Wedelia trilobata (L.) Hitch (WT), commonly known as yellow dots or creeping daisy, is a shrub possessing potent biological activities, and is traditionally used a medicinal plant in Ayurveda, Siddha and Unani systems of medicines, and it has also been tried against leukemia cell line MEG- 01. In the present study, purification and screening of the plant was done for bioactive compou...

Plants have been used as sources of medicine since ancient times. Natural products extensively in Chinese, ayurvedic and folk medicine. In addition, a significant portion the world’s population still utilizes herbal Diabetes is common ailment affecting almost 463 million people world. However, current medications exert harmful after-effects on patients, while medicines fewer adverse effects. po...

SCOPE Traditional medicinal herbs are increasingly used as alternative therapies in patients with inflammatory diseases. Here we evaluated the effect of Wedelia chinensis, a medicinal herb commonly used in Asia, on the prevention of dextran sulfate sodium (DSS)-induced acute colitis in mice. General safety and the effect of different extraction methods on the bioactivity of W. chinensis were al...

Crosstalk between the androgen receptor (AR) and other signaling pathways in prostate cancer (PCa) severely affects the therapeutic outcome of hormonal therapy. Although anti-androgen therapy prolongs overall survival in PCa patients, resistance rapidly develops and is often associated with increased AR expression and upregulation of the HER2/3-AKT signaling pathway. However, single agent thera...