Complex software systems, like operating systems and middleware, have to cope with a broad range of requirements as well as strict resource constraints. Family-based software development is a promising approach to develop application-specific systems from reusable components. However, once statically configured, these systems still need to adapt at runtime according to the dynamics of the envir...

The mouse neurological mutant weaver has an atrophic cerebellar cortex with deficits in both Purkinje and granule cell number. Although granule cells are known to die postnatally shortly after their final cell division, the cause of the Purkinje cell deficit (cell death vs lack of production) is unknown. We report here a quantitative analysis of large cerebellar neurons of the weaver mutant dur...

The phenotype of substantia nigra (SN) neurons in homozygous weaver (wv/wv) mice was studied by combining patch-clamp and single-cell RT-multiplex PCR techniques in midbrain slices of 14-d-old mice. In contrast to GABAergic SN neurons, which were unaffected in homozygous weaver mice (wv/wv), dopaminergic SN neurons possessed a dramatically altered phenotype with a depolarized membrane potential...

The developing cerebellum expresses genes which encode for both neurotrophins and their receptors. The present study was designed to determine at what stages during cerebellar granule cell neurogenesis neurotrophin family molecules may act. We report here that in purified, well-characterized granule cell cultures (Gao et al., 1991; 1992), none of the neurotrophins stimulated proliferation of gr...

This paper describes an approach that combines model engineering with program transformation techniques to construct aspect weavers for general-purpose programming languages. The front-end of the weaver uses a high-level language (i.e., an aspect language) to specify aspects and is designed with a metamodel-based approach using the AMMA toolsuite. The back-end of the weaver uses transformation ...

Suppose that c is an operator on a Hilbert Space H such that the von Neumann algebra N generated by c is finite. Let τ be a faithful normal tracial state on N and set b1 = (c+ c )/2 and b2 = (c− c)/2i. Also write B for the spectral scale of {b1, b2} relative to τ . In previous work by the present authors, some joint with Nik Weaver, B has been shown to contain considerable spectral information ...